[Comparative analysis of the effectiveness of Botulinum toxin type A - hemagglutinin preparations of the Relatox and Botox complex in the treatment of patients with primary idiopathic blepharospasm].

Q3 Medicine

Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova Pub Date : 2025-01-01 DOI:10.17116/jnevro202512502186

V V Gusev, E A Makarov, O A Lvova

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引用次数: 0

Abstract

Objective: To analyze the effectiveness of Relatox (Botulinum toxin type A - hemagglutinin complex) in comparison with Botox in the treatment of primary idiopathic blepharospasm.

Material and methods: The study included clinical data for 21 patients with blepharospasm who were treated by botulinum therapy with Botox and Relatox for 3 years. The research method is a one-step retrospective analysis of medical data. Injections were carried out with a 3-month interval. On the 6th cycle, the drug was switched to Relatox. The clinical efficacy of the drugs was assessed using an 8-point Jankovich evaluation scale: the average values before the injection and 14 days after it were compared for each procedure.

Results: Mean Jankovich scale scores decreased 2.5-fold for all cycles by the second week after the procedure (4.95 pre-injection vs. 1.8 post-injection), and the mean paired Student's T-criterion for all injections was 7.14 (with a critical value of 2.021 and a significance level of p=0.05). The mean paired Student's T-criterion for Botox was -6.63 and for Relatox -7.5 (with a critical value of 2.021 and a significance level of p=0.05), indicating a high efficacy of both drugs, slightly higher for Relatox.

Conclusion: A consistent trend of increasing efficacy with regular botulinum toxin injections and greater efficacy of Relatox compared to Botox in the treatment of patients with primary idiopathic blepharospasm has been demonstrated.

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[A型肉毒毒素-血凝素制剂Relatox与肉毒毒素复合物治疗原发性特发性眼睑痉挛的疗效比较分析]。

目的：比较A型肉毒毒素-血凝素复合物（Relatox）与肉毒杆菌素治疗原发性特发性眼睑痉挛的疗效。材料和方法：本研究纳入21例眼睑痉挛患者的临床资料，这些患者采用肉毒杆菌素和Relatox联合肉毒杆菌素治疗3年。研究方法是对医学资料进行一步回顾性分析。注射间隔3个月。在第6个周期，药物切换为Relatox。采用8点Jankovich评价量表评价药物的临床疗效：比较注射前和注射后14天的平均值。结果：手术后第二周，所有周期的Jankovich评分平均下降2.5倍（注射前4.95比注射后1.8），所有注射的配对学生t标准平均为7.14（临界值为2.021，显著性水平为p=0.05）。Botox的平均配对学生t标准为-6.63，Relatox的平均配对学生t标准为-7.5（临界值为2.021，显著性水平p=0.05），表明两种药物的疗效都很高，Relatox的疗效略高。结论：在原发性特发性眼睑痉挛患者的治疗中，定期注射肉毒杆菌毒素有提高疗效的一致趋势，并且与肉毒杆菌相比，Relatox的疗效更高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova 医学-精神病学

CiteScore

1.10

自引率

0.00%

发文量

287

审稿时长

3-6 weeks

期刊介绍： Одно из старейших медицинских изданий России, основанное в 1901 году. Создание журнала связано с именами выдающихся деятелей отечественной медицины, вошедших в историю мировой психиатрии и неврологии, – С.С. Корсакова и А.Я. Кожевникова. Широкий диапазон предлагаемых журналом материалов и разнообразие форм их представления привлекают внимание научных работников и врачей, опытных и начинающих медиков, причем не только неврологов и психиатров, но и специалистов смежных областей медицины.