Ambient Pressure Sensitivity of Subharmonic Vibrating Single Microbubbles

IF 2.4 3区医学 Q2 ACOUSTICS

Ultrasound in Medicine and Biology Pub Date : 2025-03-04 DOI:10.1016/j.ultrasmedbio.2025.01.016

Sander Spiekhout , Yuchen Wang , Tim Segers , Klazina Kooiman , Michel Versluis , Jason Voorneveld , Nico de Jong , Johannes G. Bosch

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引用次数: 0

Abstract

Objective

The response of ultrasound contrast agents is sensitive to ambient pressure, especially via their scattered subharmonic signal, which makes them a promising candidate for non-invasive pressure measurements in vivo. This work aimed to understand the sensitivity to ambient pressure of subharmonic oscillations from single microbubbles.

Methods

The subharmonic oscillation amplitude of single microbubbles in response to varying ambient pressure was studied both experimentally and numerically. In experiment, approximately 2200 single microbubbles from a monodisperse population were measured at a driving frequency close to twice their resonance frequency.

Results

The results of the numerical simulations and experiments show that a pressure change leads to a small size change in the bubble that then changes the lipid packing density, and with that the stiffness of the bubble shell.

Conclusion

The dependency of subharmonic oscillation amplitude to changes in ambient pressure can be explained by a shift in the resonance frequency of the bubble as a function of ambient pressure. The subharmonic response increases with ambient pressure when the resonance frequency shifts toward half the driving frequency and decreases when the resonance frequency shifts away from half the driving frequency. These findings help to understand non-invasive pressure sensing through subharmonic ultrasound imaging.

查看原文本刊更多论文

次谐波振动单微泡的环境压力敏感性。

目的：超声造影剂对环境压力的响应敏感，特别是通过其散射次谐波信号，使其成为无创体内压力测量的有希望的候选物。本工作旨在了解单个微泡的次谐波振荡对环境压力的敏感性。方法：采用实验和数值方法研究了单个微泡在不同环境压力下的次谐波振荡幅度。在实验中，在接近其共振频率两倍的驱动频率下，测量了来自单分散种群的大约2200个单个微泡。结果：数值模拟和实验结果表明，压力的变化会引起气泡的微小尺寸变化，从而改变脂质堆积密度，从而改变气泡壳的刚度。结论：气泡的谐振频率随环境压力的变化而变化，这可以解释为次谐波振荡幅度的变化。当谐振频率向驱动频率的一半移动时，次谐波响应随环境压力的增大而增大，当谐振频率远离驱动频率的一半时，次谐波响应减小。这些发现有助于理解通过亚谐波超声成像的非侵入性压力传感。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ultrasound in Medicine and Biology 医学-核医学

CiteScore

6.20

自引率

6.90%

发文量

325

审稿时长

70 days

期刊介绍： Ultrasound in Medicine and Biology is the official journal of the World Federation for Ultrasound in Medicine and Biology. The journal publishes original contributions that demonstrate a novel application of an existing ultrasound technology in clinical diagnostic, interventional and therapeutic applications, new and improved clinical techniques, the physics, engineering and technology of ultrasound in medicine and biology, and the interactions between ultrasound and biological systems, including bioeffects. Papers that simply utilize standard diagnostic ultrasound as a measuring tool will be considered out of scope. Extended critical reviews of subjects of contemporary interest in the field are also published, in addition to occasional editorial articles, clinical and technical notes, book reviews, letters to the editor and a calendar of forthcoming meetings. It is the aim of the journal fully to meet the information and publication requirements of the clinicians, scientists, engineers and other professionals who constitute the biomedical ultrasonic community.