Portal and Hepatic Vein Embolization vs Portal Venous Embolization Alone in Cirrhotic and Non-cirrhotic Swine: A Pilot Study.

IF 2.6 3区医学 Q2 PERIPHERAL VASCULAR DISEASE

Journal of Vascular and Interventional Radiology Pub Date : 2025-03-03 DOI:10.1016/j.jvir.2025.02.028

Jonathan Tefera, Tom N Kuhn, Nickolai J Matuschewski, Ellen Meister, Jana Nguyenová, Tabea Kao, Martin Mutonga, Ryan Bitar, Vinzent Kahl, Xuchen Zhang, Annabella Shewarega, Julius Chapiro, David C Madoff

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引用次数: 0

Abstract

Purpose: To evaluate the effectiveness of PVE and HVE compared to PVE in cirrhotic and non-cirrhotic swine.

Methods: Sixteen Yorkshire pigs were included in this study. In the cirrhotic group (n = 8) and non-cirrhotic group (n = 8), subjects underwent embolization according to established protocols. CT scans were acquired before and at two- and four-week intervals following the embolization. Liver volumes were segmented in the portal venous phase. Student's t-test with a significance level at p<0.05 was used.

Results: Across all swine, the FLR was significantly larger after PVE + HVE to PVE at two weeks (24.12% [95% CI: 15.36%, 32.88%] vs. 12.75% [95% CI: 7.43%, 18.07%], p = 0.021) and four weeks (23.23% [95% CI: 15.79%, 33.47%] vs. 15.08% [95% CI: 9.98%, 20.87%], p = 0.043) post-embolization. In the cirrhotic group, the FLR increase was greater following PVE + HVE compared to PVE at two weeks (20.85% [95% CI: 14.40%, 27.30%] vs. 8.66% [95% CI: 6.47%, 10.86%], p = 0.0089) and four weeks (19.27% [95% CI: 17.87%, 20.67%] vs. 13.33% [95% CI: 9.23%, 13.33%], p = 0.0003) post-embolization.

Conclusions: PVE + HVE resulted in greater FLR hypertrophy than PVE alone indicating that cirrhotic livers may benefit from the addition of HVE.

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来源期刊

Journal of Vascular and Interventional Radiology 医学-核医学

CiteScore

4.30

自引率

10.30%

发文量

942

审稿时长

90 days

期刊介绍： JVIR, published continuously since 1990, is an international, monthly peer-reviewed interventional radiology journal. As the official journal of the Society of Interventional Radiology, JVIR is the peer-reviewed journal of choice for interventional radiologists, radiologists, cardiologists, vascular surgeons, neurosurgeons, and other clinicians who seek current and reliable information on every aspect of vascular and interventional radiology. Each issue of JVIR covers critical and cutting-edge medical minimally invasive, clinical, basic research, radiological, pathological, and socioeconomic issues of importance to the field.