{"title":"Evaluation of Functional Capacity and Pulmonary Functions in Pediatric Patients With Chronic Kidney Disease: A Retrospective Study.","authors":"Irmak Çavuşoğlu, Elif Esma Safran, Sevgi Yavuz","doi":"10.1123/pes.2024-0128","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>Chronic kidney disease (CKD) affects pulmonary and cardiovascular systems. This study evaluates functional and pulmonary capacity in pediatric patients with CKD stages 1 to 5.</p><p><strong>Methods: </strong>Medical records of 30 pediatric CKD patients (stages 1-5) from December 2019 to February 2021 were analyzed. Functional capacity was assessed with the 6-minute walk test and spirometry measured pulmonary function. Data on body mass index z scores, height z scores, and CKD etiology (congenital anomalies of the kidney and urinary tract, glomerulonephritis, or others) were included. Correlation and regression analyses evaluated relationships between CKD severity, pulmonary function, and functional capacity.</p><p><strong>Results: </strong>Functional capacity worsened with CKD progression, with stage 5 patients showing the lowest 6-minute walk test distances (384 [71] m). Pulmonary function tests revealed lower forced expiratory volume in 1 second and peak expiratory flow values compared with healthy peers (P = .04, P < .001). Restrictive patterns were observed in early CKD, with obstructive changes in advanced stages. Positive correlations were noted between 6-minute walk test and forced expiratory volume in 1 second (r = .42) and peak expiratory flow (r = .48). Height z score emerged as an independent predictor of pulmonary outcomes.</p><p><strong>Conclusions: </strong>CKD progressively impairs functional and pulmonary capacity in children, especially in advanced stages. These findings underline the importance of comprehensive care focusing on physical and respiratory health. Prospective studies are needed to validate these results and develop targeted interventions.</p>","PeriodicalId":49712,"journal":{"name":"Pediatric Exercise Science","volume":" ","pages":"1-8"},"PeriodicalIF":1.4000,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pediatric Exercise Science","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1123/pes.2024-0128","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"PEDIATRICS","Score":null,"Total":0}
引用次数: 0
Abstract
Purpose: Chronic kidney disease (CKD) affects pulmonary and cardiovascular systems. This study evaluates functional and pulmonary capacity in pediatric patients with CKD stages 1 to 5.
Methods: Medical records of 30 pediatric CKD patients (stages 1-5) from December 2019 to February 2021 were analyzed. Functional capacity was assessed with the 6-minute walk test and spirometry measured pulmonary function. Data on body mass index z scores, height z scores, and CKD etiology (congenital anomalies of the kidney and urinary tract, glomerulonephritis, or others) were included. Correlation and regression analyses evaluated relationships between CKD severity, pulmonary function, and functional capacity.
Results: Functional capacity worsened with CKD progression, with stage 5 patients showing the lowest 6-minute walk test distances (384 [71] m). Pulmonary function tests revealed lower forced expiratory volume in 1 second and peak expiratory flow values compared with healthy peers (P = .04, P < .001). Restrictive patterns were observed in early CKD, with obstructive changes in advanced stages. Positive correlations were noted between 6-minute walk test and forced expiratory volume in 1 second (r = .42) and peak expiratory flow (r = .48). Height z score emerged as an independent predictor of pulmonary outcomes.
Conclusions: CKD progressively impairs functional and pulmonary capacity in children, especially in advanced stages. These findings underline the importance of comprehensive care focusing on physical and respiratory health. Prospective studies are needed to validate these results and develop targeted interventions.
期刊介绍：
Pediatric Exercise Science is a journal committed to enriching the scientific knowledge of exercise during childhood and adolescence. To this end it publishes information that contributes to an understanding of (a) the unique aspects of the physiologic, physical, biochemical, and psychologic responses of children to exercise, (b) the role of exercise in the treatment of pediatric chronic diseases, (c) the importance of physical activity in the prevention of illness and preservation of wellness, and (d) the means by which participation in sports may be made safer and more enjoyable for children and youth. Consideration will be given for publication of work by various methodologies consistent with the scientific approach.
Besides original research, the journal includes review articles, abstracts from other journals, book reviews, and editorial comments. Pediatric Exercise Science encourages the expression of conflicting opinions regarding children and exercise by providing a forum for alternative viewpoints. At the same time it serves as a means of accumulating a base of research information that will allow application of experimental data to clinical practice. The scientific disciplines contributing to this body of knowledge are diverse. Therefore it is the purpose of this journal to provide a common focus for disseminating advances in the science of exercise during childhood. In doing so, the journal allows the opportunity for cross-fertilization of ideas between disciplines that will potentiate the growth of knowledge in this field. Pediatric Exercise Science seeks to stimulate new ideas regarding exercise in children and to increase the awareness of scientists, health care providers, and physical educators of the importance of exercise during childhood.
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