Perturbations in the neuroactive ligand-receptor interaction and renin angiotensin system pathways are associated with cancer-related cognitive impairment.

IF 2.8 3区医学 Q2 HEALTH CARE SCIENCES & SERVICES

Supportive Care in Cancer Pub Date : 2025-03-06 DOI:10.1007/s00520-025-09317-9

Raymond J Chan, Adam Walker, Janette Vardy, Alexandre Chan, Kate Oppegaard, Yvette P Conley, Steven M Paul, Kord M Kober, Carolyn Harris, Joosun Shin, Lisa Morse, Ritu Roy, Adam Olshen, Marilyn J Hammer, Jon D Levine, Christine Miaskowski

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引用次数: 0

Abstract

Purpose: This study reports on the results from our data-driven approach that identified perturbations in neuroactive ligand-receptor interaction and renin-angiotensin system (RAS) pathways in oncology patients with and without self-reported cancer-related cognitive impairment (CRCI).

Methods: In a sample of oncology patients receiving chemotherapy (n = 1343), the Attentional Function Index (AFI) was used to assess CRCI. Patients were grouped into low (AFI score of < 5) versus high (AFI score of > 7.5) levels of cognitive function. Gene expression analyses were done using RNA-seq (n = 185) and microarray (n = 158) technologies. Pathway impact analysis was used to evaluate for perturbations in biological pathways associated with self-reported CRCI.

Results: The combined pathway impact analysis revealed that the neuroactive ligand-receptor interaction and RAS pathways were significantly perturbed between the patients with low versus high AFI scores.

Conclusions: Findings from this study suggest that in addition to inflammatory pathways, numerous mechanisms may contribute to the underlying mechanisms for the development and/or persistence of self-reported CRCI.

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目的：本研究报告了我们的数据驱动方法的结果，该方法确定了有和没有自我报告癌症相关认知障碍（CRCI）的肿瘤患者的神经活性配体-受体相互作用和肾素-血管紧张素系统（RAS）通路的干扰：在接受化疗的肿瘤患者样本中（n = 1343），使用注意功能指数（AFI）评估 CRCI。患者被分为认知功能低水平组（AFI 得分为 7.5 分）。基因表达分析采用 RNA-seq（185 人）和芯片（158 人）技术进行。利用通路影响分析评估了与自我报告的 CRCI 相关的生物通路的干扰：结果：综合通路影响分析表明，神经活性配体-受体相互作用通路和 RAS 通路在 AFI 得分低和高的患者之间存在明显的干扰：本研究结果表明，除炎症途径外，许多机制也可能是导致自我报告的 CRCI 发生和/或持续存在的根本原因。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Supportive Care in Cancer 医学-康复医学

CiteScore

5.70

自引率

9.70%

发文量

751

审稿时长

3 months

期刊介绍： Supportive Care in Cancer provides members of the Multinational Association of Supportive Care in Cancer (MASCC) and all other interested individuals, groups and institutions with the most recent scientific and social information on all aspects of supportive care in cancer patients. It covers primarily medical, technical and surgical topics concerning supportive therapy and care which may supplement or substitute basic cancer treatment at all stages of the disease. Nursing, rehabilitative, psychosocial and spiritual issues of support are also included.