Jun He, Xinyu Zhang, Zhili Ge, Jingjing Shi, Shuwen Guo, Jun Chen
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引用次数: 0
Abstract
Whole-body cryotherapy (WBC) is increasingly being studied and used in various populations, mainly focusing on improving the body's regenerative capacity. More comprehensive summaries of anti-inflammatory responses are needed. To systemically assess the effect of WBC on the inflammatory response in humans based on randomized controlled trials (RCTs). Articles about RCTs accessing the effects of whole-body cryotherapy on the levels of inflammatory factors in humans published until August 1, 2024 had been searched in PubMed, Web of Science, Embase and Cochrane library databases. The general information of the included articles and exposure mode, the types and levels of inflammatory factors in serum were extracted. The PEDro scale was used to assess the risk of bias, and the GRADE scale was used to assess the level of certainty of evidence. RevMan 5.4 software were used to conduct the meta-analysis. A total of 11 RCTs in 11 articles were included, and the total sample size was 274. The level of IL-1β in serum of people exposed to WBC was lower than that in control group (SMD value was - 2.08pg/mL, P < 0.05), and athletes exposed to WBC were more likely to benefit from this. The level of IL-10 in serum of people exposed to WBC was higher than that in control group ( SMD value was 0.78 pg/mL, P < 0.05), and obese people exposed to WBC were more likely to benefit from this than athletes. WBC effectively reduces inflammation by lowering IL-1β and increasing IL-10 levels, offering significant benefits for athletes and obese individuals.
全身冷冻疗法(WBC)越来越多地被研究和应用于各种人群,主要集中在提高身体的再生能力。需要更全面的抗炎反应总结。以随机对照试验(RCTs)为基础,系统评估白细胞对人类炎症反应的影响。在PubMed、Web of Science、Embase和Cochrane图书馆数据库中检索了截至2024年8月1日发表的关于全身冷冻疗法对人类炎症因子水平影响的随机对照试验的文章。提取纳入文献的一般信息、暴露方式、血清炎症因子的类型和水平。PEDro量表用于评估偏倚风险,GRADE量表用于评估证据的确定性水平。采用RevMan 5.4软件进行meta分析。共纳入11篇文章的11项rct,总样本量为274例。白细胞接触者血清IL-1β水平低于对照组(SMD值为- 2.08pg/mL, P
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