Hepatic Stellate Cells Functional Heterogeneity in Liver Cancer.

IF 3.7 3区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Seminars in liver disease Pub Date : 2025-03-01 Epub Date: 2025-03-05 DOI:10.1055/a-2551-0724

Laura Sererols-Viñas, Gemma Garcia-Vicién, Paloma Ruiz-Blázquez, Ting-Fang Lee, Youngmin A Lee, Ester Gonzalez-Sanchez, Javier Vaquero, Anna Moles, Aveline Filliol, Silvia Affò

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引用次数: 0

Abstract

Hepatic stellate cells (HSCs) are the liver's pericytes, and play key roles in liver homeostasis, regeneration, fibrosis, and cancer. Upon injury, HSCs activate and are the main origin of myofibroblasts and cancer-associated fibroblasts (CAFs) in liver fibrosis and cancer. Primary liver cancer has a grim prognosis, ranking as the third leading cause of cancer-related deaths worldwide, with hepatocellular carcinoma (HCC) being the predominant type, followed by intrahepatic cholangiocarcinoma (iCCA). Moreover, the liver hosts 35% of all metastatic lesions. The distinct spatial distribution and functional roles of HSCs across these malignancies represent a significant challenge for universal therapeutic strategies, requiring a nuanced and tailored understanding of their contributions. This review examines the heterogeneous roles of HSCs in liver cancer, focusing on their spatial localization, dynamic interactions within the tumor microenvironment (TME), and emerging therapeutic opportunities, including strategies to modulate their activity, and harness their potential as targets for antifibrotic and antitumor interventions.

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肝星状细胞在肝癌中的功能异质性。

肝星状细胞（HSCs）是肝脏的周细胞，在肝脏稳态、再生、纤维化和癌变中起关键作用。损伤后，造血干细胞被激活，是肝纤维化和癌症中肌成纤维细胞和癌症相关成纤维细胞（CAFs）的主要来源。原发性肝癌预后恶劣，在全球癌症相关死亡原因中排名第三，其中以肝细胞癌（HCC）居多，其次为肝内胆管癌（iCCA）。此外，35%的转移性病变发生在肝脏。造血干细胞在这些恶性肿瘤中的独特空间分布和功能作用对通用治疗策略提出了重大挑战，需要对其贡献进行细致和量身定制的理解。本文综述了造血干细胞在肝癌中的异质性作用，重点关注其空间定位，肿瘤微环境（TME）内的动态相互作用，以及新兴的治疗机会，包括调节其活性的策略，以及利用其作为抗纤维化和抗肿瘤干预靶点的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Seminars in liver disease 医学-胃肠肝病学

CiteScore

8.20

自引率

2.40%

发文量

期刊介绍： Seminars in Liver Disease is a quarterly review journal that publishes issues related to the specialties of hepatology and gastroenterology. As the premiere review journal in the field, Seminars in Liver Disease provides in-depth coverage with articles and issues focusing on topics such as cirrhosis, transplantation, vascular and coagulation disorders, cytokines, hepatitis B & C, Nonalcoholic Steatosis Syndromes (NASH), pediatric liver diseases, hepatic stem cells, porphyrias as well as a myriad of other diseases related to the liver. Attention is also given to the latest developments in drug therapy along with treatment and current management techniques. Seminars in Liver Disease publishes commissioned reviews. Unsolicited reviews of an exceptional nature or original articles presenting remarkable results will be considered, but case reports will not be published.