Dermabond Prineo: a systematic review and meta-analysis.

IF 1.5 4区医学 Q3 DERMATOLOGY

Journal of wound care Pub Date : 2025-03-02 DOI:10.12968/jowc.2023.0024

Shreya Kulkarni, Matthew Goodbun, Mohammed Chowdhury, Philip W Stather

{"title":"Dermabond Prineo: a systematic review and meta-analysis.","authors":"Shreya Kulkarni, Matthew Goodbun, Mohammed Chowdhury, Philip W Stather","doi":"10.12968/jowc.2023.0024","DOIUrl":null,"url":null,"abstract":"Objective: Dermabond Prineo (Ethicon Inc., US) is a combination of a skin adhesive applied over a polyester mesh to reinforce and share tension equally over the surgical wound with the aim of reducing closure time and improving wound healing. The aims of this systematic review were to assess published data on Dermabond Prineo regarding infection rates, delayed wound healing, cosmetic appearance and application time compared to conventional wound closure techniques across multiple surgical procedures.Method: A literature search was conducted according to PRISMA guidelines. The primary outcome was the incidence of wound infection after Dermabond Prineo compared to controls, namely traditional methods of wound closure such as staples, sutures and adhesives. Secondary outcome measures included allergic reactions and time taken for application.Results: A literature search using PubMed, SCOPUS and Science Direct identified 52 studies, of which 19 were eligible for qualitative synthesis and 12 for meta-analysis. The studies included reflected a broad range of applications of Dermabond Prineo for wound closure in abdominoplasty, mammoplasty and arthroplasty. Overall, all studies reporting on time taken for application found that Dermabond Prineo reduced time for wound closure. Meta-analysis identified a statistically significant reduction in wound infection rates (Dermabond Prineo 1.51%, control 2.13%; OR: 0.65 (0.46, 0.91); p=0.01) and a reduction in delayed wound healing (Dermabond Prineo 0.99%, control 1.79%; OR: 0.42 (0.18, 0.98); p=0.05). All three studies reporting on outcomes of scar cosmesis or long-term maturation attested to improved cosmetic results compared with sutures. The cost-effectiveness of Dermabond Prineo with a hypothetical model was discussed in two studies which concluded that it could achieve savings of $50-76 USD per patient, while a retrospective model found no statistically significant difference in total hospital costs or operating room time.Conclusion: In this review, Dermabond Prineo showed lower wound infection rates and a reduction in delayed wound healing. Further studies are required to assess cost-effectiveness in a real-world setting.","PeriodicalId":17590,"journal":{"name":"Journal of wound care","volume":"34 3","pages":"220-226"},"PeriodicalIF":1.5000,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of wound care","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.12968/jowc.2023.0024","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"DERMATOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Objective: Dermabond Prineo (Ethicon Inc., US) is a combination of a skin adhesive applied over a polyester mesh to reinforce and share tension equally over the surgical wound with the aim of reducing closure time and improving wound healing. The aims of this systematic review were to assess published data on Dermabond Prineo regarding infection rates, delayed wound healing, cosmetic appearance and application time compared to conventional wound closure techniques across multiple surgical procedures.

Method: A literature search was conducted according to PRISMA guidelines. The primary outcome was the incidence of wound infection after Dermabond Prineo compared to controls, namely traditional methods of wound closure such as staples, sutures and adhesives. Secondary outcome measures included allergic reactions and time taken for application.

Results: A literature search using PubMed, SCOPUS and Science Direct identified 52 studies, of which 19 were eligible for qualitative synthesis and 12 for meta-analysis. The studies included reflected a broad range of applications of Dermabond Prineo for wound closure in abdominoplasty, mammoplasty and arthroplasty. Overall, all studies reporting on time taken for application found that Dermabond Prineo reduced time for wound closure. Meta-analysis identified a statistically significant reduction in wound infection rates (Dermabond Prineo 1.51%, control 2.13%; OR: 0.65 (0.46, 0.91); p=0.01) and a reduction in delayed wound healing (Dermabond Prineo 0.99%, control 1.79%; OR: 0.42 (0.18, 0.98); p=0.05). All three studies reporting on outcomes of scar cosmesis or long-term maturation attested to improved cosmetic results compared with sutures. The cost-effectiveness of Dermabond Prineo with a hypothetical model was discussed in two studies which concluded that it could achieve savings of $50-76 USD per patient, while a retrospective model found no statistically significant difference in total hospital costs or operating room time.

Conclusion: In this review, Dermabond Prineo showed lower wound infection rates and a reduction in delayed wound healing. Further studies are required to assess cost-effectiveness in a real-world setting.

查看原文本刊更多论文

Dermabond Prineo：系统回顾和荟萃分析。

目的：Dermabond Prineo （Ethicon公司，美国）是一种结合了皮肤胶粘剂的产品，应用于聚酯网，在手术伤口上均匀地加强和分担张力，目的是减少闭合时间，促进伤口愈合。本系统综述的目的是评估已发表的关于Dermabond Prineo的感染率、伤口愈合延迟、美容外观和应用时间的数据，与传统的伤口愈合技术相比，在多个手术过程中。方法：根据PRISMA指南进行文献检索。主要观察结果是与对照组相比，皮术后伤口感染的发生率，即传统的缝合方法，如订书钉、缝合线和粘接剂。次要结果测量包括过敏反应和应用时间。结果：通过PubMed、SCOPUS和Science Direct进行文献检索，确定了52项研究，其中19项符合定性综合，12项符合元分析。这些研究反映了Dermabond Prineo在腹部成形术、乳房成形术和关节成形术中伤口愈合的广泛应用。总的来说，所有报告应用时间的研究发现，Dermabond Prineo减少了伤口愈合的时间。meta分析发现，伤口感染率显著降低(Dermabond Prineo组1.51%，对照组2.13%；Or: 0.65 (0.46, 0.91)；p=0.01)和延迟伤口愈合的减少(Dermabond Prineo 0.99%, control 1.79%；Or: 0.42 (0.18, 0.98)；p = 0.05)。所有三个报告疤痕美容或长期成熟结果的研究证明，与缝合相比，美容效果有所改善。两项研究讨论了假设模型下Dermabond Prineo的成本-效果，结论为每位患者可节省50-76美元，而回顾性模型发现医院总费用或手术室时间无统计学差异。结论：在本综述中，Dermabond Prineo具有较低的伤口感染率和减少伤口延迟愈合的作用。需要进一步的研究来评估现实环境中的成本效益。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of wound care DERMATOLOGY-

CiteScore

2.90

自引率

10.50%

发文量

215

期刊介绍： Journal of Wound Care (JWC) is the definitive wound-care journal and the leading source of up-to-date research and clinical information on everything related to tissue viability. The journal was first launched in 1992 and aimed at catering to the needs of the multidisciplinary team. Published monthly, the journal’s international audience includes nurses, doctors and researchers specialising in wound management and tissue viability, as well as generalists wishing to enhance their practice. In addition to cutting edge and state-of-the-art research and practice articles, JWC also covers topics related to wound-care management, education and novel therapies, as well as JWC cases supplements, a supplement dedicated solely to case reports and case series in wound care. All articles are rigorously peer-reviewed by a panel of international experts, comprised of clinicians, nurses and researchers. Specifically, JWC publishes: High quality evidence on all aspects of wound care, including leg ulcers, pressure ulcers, the diabetic foot, burns, surgical wounds, wound infection and more The latest developments and innovations in wound care through both preclinical and preliminary clinical trials of potential new treatments worldwide In-depth prospective studies of new treatment applications, as well as high-level research evidence on existing treatments Clinical case studies providing information on how to deal with complex wounds Comprehensive literature reviews on current concepts and practice, including cost-effectiveness Updates on the activities of wound care societies around the world.