U-shaped relationship between body mass index and intracerebral hemorrhage-related functional decline.

IF 1.7 4区医学 Q3 CLINICAL NEUROLOGY

Neurological Research Pub Date : 2025-04-01 Epub Date: 2025-03-05 DOI:10.1080/01616412.2025.2472843

Yuji Kanejima, Masato Ogawa, Kodai Ishihara, Naofumi Yoshida, Michikazu Nakai, Koshiro Kanaoka, Yoko Sumita, Takuo Emoto, Yoshitada Sakai, Yoshitaka Iwanaga, Yoshihiro Miyamoto, Tomoya Yamashita, Kenichi Hirata, Kazuhiro P Izawa

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引用次数: 0

Abstract

Background: Body mass index (BMI) is associated with the sites of intracerebral hemorrhage (ICH), which affect functional decline. However, the optimal BMI range for minimizing functional decline remains unclear. This study aimed to clarify the relationship between BMI and ICH-related functional decline.

Methods: ICH survivors registered in the Japanese Registry Of All Cardiac and Vascular Diseases Diagnosis Procedure Combination (JROAD-DPC) database from April 2016 to March 2020 were included. BMI was categorized according to the World Health Organization Asia-Pacific classification. The primary outcome was ICH-related functional decline, defined as an increase in the modified Rankin Scale (mRS) score at discharge compared to pre-stroke.

Results: This study included 155,211 patients with ICH, with a mean BMI of 22.3 kg/m². Among these patients, 74.1% experienced ICH-related functional decline. The overweight group (23.0 < BMI ≤ 25.0 kg/m²) exhibited the lowest rate of functional decline (Odds ratio: 0.90, 95% CI: 0.85-0.94). The relationship between BMI and ICH-related functional decline followed a U-shaped curve, indicating that a BMI range of 22.2-30.4 kg/m² was associated with reduced odds of functional decline.

Conclusion: In patients with ICH, both extremely low and high BMIs were associated with a higher likelihood of functional decline post-ICH onset. Maintaining a BMI within the range of 22.2-30.4 kg/m² may be beneficial for reducing the risk of functional decline.

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身体质量指数与脑出血相关功能下降呈u型关系。

背景：身体质量指数（BMI）与脑出血（ICH）部位相关，影响功能衰退。然而，减少功能衰退的最佳BMI范围仍不清楚。本研究旨在阐明BMI与ich相关功能下降之间的关系。方法：纳入2016年4月至2020年3月在日本所有心血管疾病诊断程序组合登记处（JROAD-DPC）数据库中登记的ICH幸存者。BMI根据世界卫生组织亚太地区的分类进行分类。主要结局是与脑出血相关的功能下降，定义为出院时改良兰金量表（mRS）评分较卒中前升高。结果：本研究纳入脑出血患者155,211例，平均BMI为22.3 kg/m2。在这些患者中，74.1%出现了与ich相关的功能下降。超重组（23.0 < BMI≤25.0 kg/m2）功能下降率最低（优势比：0.90,95% CI: 0.85 ~ 0.94）。BMI与ich相关功能下降的关系呈u型曲线，表明BMI在22.2-30.4 kg/m2范围内与功能下降的几率降低相关。结论：在脑出血患者中，极低和极高的bmi与脑出血后功能下降的可能性相关。将BMI维持在22.2-30.4 kg/m2范围内可能有利于降低功能衰退的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurological Research 医学-临床神经学

CiteScore

3.60

自引率

0.00%

发文量

116

审稿时长

5.3 months

期刊介绍： Neurological Research is an international, peer-reviewed journal for reporting both basic and clinical research in the fields of neurosurgery, neurology, neuroengineering and neurosciences. It provides a medium for those who recognize the wider implications of their work and who wish to be informed of the relevant experience of others in related and more distant fields. The scope of the journal includes: •Stem cell applications •Molecular neuroscience •Neuropharmacology •Neuroradiology •Neurochemistry •Biomathematical models •Endovascular neurosurgery •Innovation in neurosurgery.