U-shaped relationship between body mass index and intracerebral hemorrhage-related functional decline.

IF 1.7 4区医学 Q3 CLINICAL NEUROLOGY

Neurological Research Pub Date : 2025-04-01 Epub Date: 2025-03-05 DOI:10.1080/01616412.2025.2472843

Yuji Kanejima, Masato Ogawa, Kodai Ishihara, Naofumi Yoshida, Michikazu Nakai, Koshiro Kanaoka, Yoko Sumita, Takuo Emoto, Yoshitada Sakai, Yoshitaka Iwanaga, Yoshihiro Miyamoto, Tomoya Yamashita, Kenichi Hirata, Kazuhiro P Izawa

{"title":"U-shaped relationship between body mass index and intracerebral hemorrhage-related functional decline.","authors":"Yuji Kanejima, Masato Ogawa, Kodai Ishihara, Naofumi Yoshida, Michikazu Nakai, Koshiro Kanaoka, Yoko Sumita, Takuo Emoto, Yoshitada Sakai, Yoshitaka Iwanaga, Yoshihiro Miyamoto, Tomoya Yamashita, Kenichi Hirata, Kazuhiro P Izawa","doi":"10.1080/01616412.2025.2472843","DOIUrl":null,"url":null,"abstract":"Background: Body mass index (BMI) is associated with the sites of intracerebral hemorrhage (ICH), which affect functional decline. However, the optimal BMI range for minimizing functional decline remains unclear. This study aimed to clarify the relationship between BMI and ICH-related functional decline.Methods: ICH survivors registered in the Japanese Registry Of All Cardiac and Vascular Diseases Diagnosis Procedure Combination (JROAD-DPC) database from April 2016 to March 2020 were included. BMI was categorized according to the World Health Organization Asia-Pacific classification. The primary outcome was ICH-related functional decline, defined as an increase in the modified Rankin Scale (mRS) score at discharge compared to pre-stroke.Results: This study included 155,211 patients with ICH, with a mean BMI of 22.3 kg/m2. Among these patients, 74.1% experienced ICH-related functional decline. The overweight group (23.0 < BMI ≤ 25.0 kg/m2) exhibited the lowest rate of functional decline (Odds ratio: 0.90, 95% CI: 0.85-0.94). The relationship between BMI and ICH-related functional decline followed a U-shaped curve, indicating that a BMI range of 22.2-30.4 kg/m2 was associated with reduced odds of functional decline.Conclusion: In patients with ICH, both extremely low and high BMIs were associated with a higher likelihood of functional decline post-ICH onset. Maintaining a BMI within the range of 22.2-30.4 kg/m2 may be beneficial for reducing the risk of functional decline.","PeriodicalId":19131,"journal":{"name":"Neurological Research","volume":" ","pages":"296-305"},"PeriodicalIF":1.7000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neurological Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/01616412.2025.2472843","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/3/5 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Body mass index (BMI) is associated with the sites of intracerebral hemorrhage (ICH), which affect functional decline. However, the optimal BMI range for minimizing functional decline remains unclear. This study aimed to clarify the relationship between BMI and ICH-related functional decline.

Methods: ICH survivors registered in the Japanese Registry Of All Cardiac and Vascular Diseases Diagnosis Procedure Combination (JROAD-DPC) database from April 2016 to March 2020 were included. BMI was categorized according to the World Health Organization Asia-Pacific classification. The primary outcome was ICH-related functional decline, defined as an increase in the modified Rankin Scale (mRS) score at discharge compared to pre-stroke.

Results: This study included 155,211 patients with ICH, with a mean BMI of 22.3 kg/m². Among these patients, 74.1% experienced ICH-related functional decline. The overweight group (23.0 < BMI ≤ 25.0 kg/m²) exhibited the lowest rate of functional decline (Odds ratio: 0.90, 95% CI: 0.85-0.94). The relationship between BMI and ICH-related functional decline followed a U-shaped curve, indicating that a BMI range of 22.2-30.4 kg/m² was associated with reduced odds of functional decline.

Conclusion: In patients with ICH, both extremely low and high BMIs were associated with a higher likelihood of functional decline post-ICH onset. Maintaining a BMI within the range of 22.2-30.4 kg/m² may be beneficial for reducing the risk of functional decline.

查看原文本刊更多论文

求助全文

约1分钟内获得全文求助全文

来源期刊

Neurological Research 医学-临床神经学

CiteScore

3.60

自引率

0.00%

发文量

116

审稿时长

5.3 months

期刊介绍： Neurological Research is an international, peer-reviewed journal for reporting both basic and clinical research in the fields of neurosurgery, neurology, neuroengineering and neurosciences. It provides a medium for those who recognize the wider implications of their work and who wish to be informed of the relevant experience of others in related and more distant fields. The scope of the journal includes: •Stem cell applications •Molecular neuroscience •Neuropharmacology •Neuroradiology •Neurochemistry •Biomathematical models •Endovascular neurosurgery •Innovation in neurosurgery.