F-wave motor unit numbers do not change in diabetic polyneuropathy: does it indicate a pathophysiologic mechanism for generating F-waves?

IF 1.7 4区 医学 Q3 CLINICAL NEUROLOGY
Isil Yazıcı Gencdal, Nermin Gorkem Sirin, Tugrul Artug, Irem Ilgezdi, Ummu Mutlu, Elif Kocasoy-Orhan, Mehmet Baris Baslo, Nevin Dinccag, Ali Emre Oge
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引用次数: 0

Abstract

Objectives: Motor unit number estimation (MUNE) methods including the one using F-waves (F-MUNE) are used to detect axonal loss in polyneuropathies. The aim of this study is to evaluate the amount of axonal loss by repeater F-wave parameters and F-MUNE in patients with type 2 diabetes mellitus (DM).

Methods: In 24 controls and 49 patients with diabetic polyneuropathy, 90 F-waves elicited with supramaximal and 300 F-waves with submaximal stimulation of the ulnar nerve were recorded from the abductor digiti minimi muscle. F-MUNE values were calculated using the automated software with the repeater F-waves elicited using submaximal stimulation.

Results: Ulnar repeater F-wave index and repeater neuron index were found to be significantly higher in patients with DM compared with the control group. The amplitudes of F-waves elicited using both sub- and supramaximal stimulus intensities were reduced in patients with polyneuropathy when compared with controls. The F-MUNE values were found to be similar between the two groups.

Discussion: Repeater F-wave parameters recorded from the upper extremity might indicate the presence of axon loss in DM-related polyneuropathy. However, F-MUNE failed to reveal axonal loss in diabetic polyneuropathy probably because of its length-dependent nature and the dominance of low-amplitude F-waves, which might be secondary to several yet unknown mechanisms, mainly related to sensory fiber dysfunction.

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来源期刊
Neurological Research
Neurological Research 医学-临床神经学
CiteScore
3.60
自引率
0.00%
发文量
116
审稿时长
5.3 months
期刊介绍: Neurological Research is an international, peer-reviewed journal for reporting both basic and clinical research in the fields of neurosurgery, neurology, neuroengineering and neurosciences. It provides a medium for those who recognize the wider implications of their work and who wish to be informed of the relevant experience of others in related and more distant fields. The scope of the journal includes: •Stem cell applications •Molecular neuroscience •Neuropharmacology •Neuroradiology •Neurochemistry •Biomathematical models •Endovascular neurosurgery •Innovation in neurosurgery.
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