Incidence of Arrhythmias in Chronic Obstructive Pulmonary Disease, Obstructive Sleep Apnea and Overlap Syndrome: A Retrospective Cohort Study.

IF 5.6 2区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Heart rhythm Pub Date : 2025-03-03 DOI:10.1016/j.hrthm.2025.02.042

Hoang Nhat Pham, Christopher Kanaan, Ramzi Ibrahim, Mahmoud Abdelnabi, Sabrina Soin, George Bcharah, Eiad Habib, Omar Baqal, Juan Farina, Jiang Xie, Amitoj Singh, Chadi Ayoub, Reza Arsanjani, Justin Z Lee, Hicham El Masry, Dan Sorajja, Anwar A Chahal

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引用次数: 0

Abstract

Background: New-onset arrhythmias are common in patients with chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA). However, scarce data exists regarding arrhythmia risk in overlap syndrome (OS), encompassing COPD and OSA.

Objective: We compared the incidence of new onset atrial and ventricular arrhythmias in patients with COPD, OSA, and OS.

Methods: We conducted a retrospective cohort study using the TriNetX Network, comprising >140 million patients to identify patients with COPD, OSA, and OS. Patients with pre-existing arrhythmias were excluded. Propensity score matching (PSM) was used to adjust for demographics, comorbidities, and medications. Adjusted odds ratios (aORs) were estimated to compare incidence of arrhythmias across cohorts.

Results: Between 2010-2020, a total of 2,438,454 patients with COPD-only, 1,960,845 with OSA-only, and 440,018 with OS (age≥18 years) were identified. After PSM, we included 359,496 patients per cohort for the OS versus OSA-only comparison and 399,235 patients per cohort for the OS versus COPD-only comparison. Over a mean follow-up of 5.3 years, new-onset atrial fibrillation/flutter incidence was 10.0% in OS vs. 7.0% in COPD (aOR 1.472, 95%CI 1.449-1.496) and 6.4% in OSA (aOR 1.568, 95%CI 1.541-1.595). Patients with OS had higher incidence of new-onset ventricular tachycardia and cardiac arrest than those with COPD (aOR 1.442 and 1.189, respectively) and OSA (aOR 1.645 and 1.777, respectively). Patients with COPD preceding OSA diagnosis had higher odds of new-onset arrhythmias.

Conclusion: Patients with OS have a higher incidence of new-onset atrial fibrillation/flutter, ventricular tachycardia, and cardiac arrest compared to those with OSA and COPD alone.

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来源期刊

Heart rhythm 医学-心血管系统

CiteScore

10.50

自引率

5.50%

发文量

1465

审稿时长

24 days

期刊介绍： HeartRhythm, the official Journal of the Heart Rhythm Society and the Cardiac Electrophysiology Society, is a unique journal for fundamental discovery and clinical applicability. HeartRhythm integrates the entire cardiac electrophysiology (EP) community from basic and clinical academic researchers, private practitioners, engineers, allied professionals, industry, and trainees, all of whom are vital and interdependent members of our EP community. The Heart Rhythm Society is the international leader in science, education, and advocacy for cardiac arrhythmia professionals and patients, and the primary information resource on heart rhythm disorders. Its mission is to improve the care of patients by promoting research, education, and optimal health care policies and standards.