Pathogenesis of pepsin-induced gastroesophageal reflux disease with advanced diagnostic tools and therapeutic implications.

IF 3.1 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL
Frontiers in Medicine Pub Date : 2025-02-19 eCollection Date: 2025-01-01 DOI:10.3389/fmed.2025.1516335
Chong Li, Xiwen Cao, Hongxia Wang
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引用次数: 0

Abstract

Gastroesophageal reflux disease (GERD) is a common gastrointestinal disorder that significantly affects populations in both developing and developed countries. Due to both intrinsic pathology and extrinsic risk factors, the incidence of GERD has risen substantially in recent decades. This disorder results from an imbalance between the esophagus's defensive mechanisms and the harmful effects of the refluxate. The pepsin, an enzyme secreted exclusively by the stomach, plays a critical role in the pathogenesis of GERD due to its invasiveness effects in acidic environments. By thoroughly understanding the pathogenesis of pepsin-induced GERD, we could better address its diagnostic and therapeutic potential in clinical practice. Although current diagnostic tools are widely used, they have several limitations. As a result, researchers have increasingly focused on the salivary pepsin test, a novel diagnostic method that utilizes the specific pathological mechanisms of pepsin. To overcome the drawbacks of the currently used salivary pepsin test, fluorescence response detection has been integrated with other technologies. Beyond its diagnostic significance, pepsin in saliva may also serve as a target for GERD management in innovative clinical trials. In this review, we summarize the latest advancements in the diagnosis and management of GERD to improve patient outcomes.

胃食管反流病(GERD)是一种常见的胃肠道疾病,严重影响着发展中国家和发达国家的人口。由于内在病理和外在风险因素,胃食管反流病的发病率近几十年来大幅上升。这种疾病是食道的防御机制与反流物的有害影响之间失衡的结果。胃蛋白酶是胃部专门分泌的一种酶,由于其在酸性环境中的侵袭作用,胃蛋白酶在胃食管反流病的发病机制中起着至关重要的作用。通过深入了解胃蛋白酶诱发胃食管反流病的发病机制,我们可以更好地在临床实践中对其进行诊断和治疗。尽管目前的诊断工具已被广泛使用,但它们仍存在一些局限性。因此,研究人员越来越关注唾液胃蛋白酶检测,这是一种利用胃蛋白酶特定病理机制的新型诊断方法。为了克服目前使用的唾液胃蛋白酶检测法的缺点,荧光反应检测法已与其他技术相结合。除了诊断意义外,唾液中的胃蛋白酶还可作为胃食管反流病治疗的目标,用于创新性临床试验。在这篇综述中,我们总结了胃食管反流病诊断和治疗的最新进展,以改善患者的治疗效果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Frontiers in Medicine
Frontiers in Medicine Medicine-General Medicine
CiteScore
5.10
自引率
5.10%
发文量
3710
审稿时长
12 weeks
期刊介绍: Frontiers in Medicine publishes rigorously peer-reviewed research linking basic research to clinical practice and patient care, as well as translating scientific advances into new therapies and diagnostic tools. Led by an outstanding Editorial Board of international experts, this multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. In addition to papers that provide a link between basic research and clinical practice, a particular emphasis is given to studies that are directly relevant to patient care. In this spirit, the journal publishes the latest research results and medical knowledge that facilitate the translation of scientific advances into new therapies or diagnostic tools. The full listing of the Specialty Sections represented by Frontiers in Medicine is as listed below. As well as the established medical disciplines, Frontiers in Medicine is launching new sections that together will facilitate - the use of patient-reported outcomes under real world conditions - the exploitation of big data and the use of novel information and communication tools in the assessment of new medicines - the scientific bases for guidelines and decisions from regulatory authorities - access to medicinal products and medical devices worldwide - addressing the grand health challenges around the world
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