The impact of non-pharmacological interventions on nasopharyngeal Staphylococcus aureus, Streptococcus pneumoniae, Moraxella catarrhalis, Haemophilus influenzae carriage and the change of pneumococcal vaccination in healthy children under 5 years old in Beijing, China.

IF 5.5 3区医学 Q1 IMMUNOLOGY

Expert Review of Vaccines Pub Date : 2025-12-01 Epub Date: 2025-03-13 DOI:10.1080/14760584.2025.2476521

Qianqian Du, Zhaoqiu Liu, Wei Shi, Xijie Liu, Qinghong Meng, Dongyi Zheng, Kaihu Yao

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引用次数: 0

Abstract

Background: We analyzed the impact of non-pharmacological interventions (NPIs) and PCV13 inoculation on nasopharyngeal (NP) carriage of Staphylococcus aureus (Sa), Streptococcus pneumoniae (Sp), Moraxella catarrhalis (Mc), and Haemophilus influenzae (Hi) in healthy children under 5-years-old in Beijing, China.

Research design and methods: NP swabs were taken from healthy children seeking routine well-child care at the pediatric preventive health clinic. NP swabs were frozen in Tryptic Soy Broth (TSB) medium and stored at -80°C, and bacterial was detected by culture.

Results: From December 2019 to November 2021, 1939 children were enrolled, among whom 278 (14.3%) were found to carry Sa isolates, 115 (5.9%) Sp, 39 (2.0%) Mc, and 6 (0.3%) Hi. The carriage of Sa was highest in infants under 6 months, negatively correlated with Sp and Mc. The Sa carriage rate in infants below 6 months of age rose from 26.7% in pre-NPIs to 32.7% in post-NPIs early. The 13-valent pneumococcal conjugate vaccine (PCV13) uptake rose from 42.3% in December 2019 to 62.3% by October 2021.

Conclusions: The broad application of NPIs caused a decline in Sp and Mc carriage among children under 5-years-old, accompanied by an elevation in the Sa carriage rate among infants.

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非药物干预对北京地区5岁以下健康儿童鼻咽金黄色葡萄球菌、肺炎链球菌、卡他莫拉菌、流感嗜血杆菌携带及肺炎球菌疫苗接种变化的影响

背景：我们分析了非药物干预（NPIs）和pcv13接种对中国北京5岁以下健康儿童鼻咽携带金黄色葡萄球菌（Sa）、肺炎链球菌（Sp）、卡他莫拉菌（Mc）和流感嗜血杆菌（Hi）的影响。研究设计和方法：NP拭子取自在儿科预防保健诊所接受常规儿童护理的健康儿童。NP拭子在Tryptic Soy Broth （TSB）培养基中冷冻，保存在-80℃，通过培养检测细菌。结果：2019年12月至2021年11月，共纳入3939例儿童，其中Sa 278例（14.3%），Sp 115例（5.9%），Mc 39例（2.0%），Hi 6例（0.3%）。6月龄以下婴儿Sa携带率最高，与Sp和Mc呈负相关。6月龄以下婴儿Sa携带率从npi前的26.7%上升到npi后早期的32.7%。13价肺炎球菌结合疫苗（PCV13）的接种率从2019年12月的42.3%上升到2021年10月的62.3%。结论：npi的广泛应用导致5岁以下儿童Sp和Mc携带率下降，同时婴儿sa携带率升高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Expert Review of Vaccines 医学-免疫学

CiteScore

9.10

自引率

3.20%

发文量

136

审稿时长

4-8 weeks

期刊介绍： Expert Review of Vaccines (ISSN 1476-0584) provides expert commentary on the development, application, and clinical effectiveness of new vaccines. Coverage includes vaccine technology, vaccine adjuvants, prophylactic vaccines, therapeutic vaccines, AIDS vaccines and vaccines for defence against bioterrorism. All articles are subject to rigorous peer-review. The vaccine field has been transformed by recent technological advances, but there remain many challenges in the delivery of cost-effective, safe vaccines. Expert Review of Vaccines facilitates decision making to drive forward this exciting field.