Comparison of the Effects of Timolol, Brinzolamide, Brimonidine and Netarsudil in a Rabbit Model of Water Loading-Induced Ocular Hypertension.

IF 1.7 4区医学 Q3 OPHTHALMOLOGY

Current Eye Research Pub Date : 2025-03-06 DOI:10.1080/02713683.2025.2472365

Junya Maruoka, Yasuhiro Takeji, Daisuke Yamashita, Keisuke Hino, Shinsaku Itoh, Yusuke Kakumoto, Kazushi Sakurai, Hiroki Urashima

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引用次数: 0

Abstract

Purpose: This study aimed to compare the intraocular pressure (IOP)-lowering effects of timolol (a β-blocker), brinzolamide (a carbonic anhydrase inhibitor), brimonidine (an α2-agonist) and netarsudil (a rho kinase inhibitor) in rabbits.

Methods: The experiments were performed on 52 female New Zealand white rabbits. The IOP was measured in normotensive rabbits and in water loading-induced ocular hypertension model rabbits. Thirty microliters of timolol, brinzolamide, brimonidine, netarsudil or saline was administered topically to the randomly chosen eye. Ocular hypertension was induced by the oral administration of 60 mL/kg of tap water.

Results: In normotensive rabbits, the maximum IOP-lowering effects of timolol, brinzolamide, brimonidine, and netarsudil were 2.9 mmHg (2 h), 5.2 mmHg (1 h), 5.7 mmHg (2 h), and 3.3 mmHg (4 h), respectively. In water loading-induced ocular hypertension model rabbits, the maximum IOP-lowering effects of timolol, brinzolamide, brimonidine, and netarsudil were 3.6, 5.0, 12.2, and 5.0 mmHg, respectively. The IOP-lowering effects of brimonidine and netarsudil were sustained until 90 min after water loading.

Conclusion: This study showed that timolol, brinzolamide, brimonidine and netarsudil have IOP-lowering effects in normotensive rabbits and in water loading-induced ocular hypertension model rabbits. In an ocular hypertension rabbit model, brimonidine and netarsudil, which promote aqueous humor outflow, exhibited stronger IOP-lowering effects than timolol and brinzolamide, which suppress aqueous humor production. These results could provide data for characterizing each medication. These data may aid in the development of new glaucoma medications through the combination of existing medications.

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替马洛尔、布林唑胺、溴莫尼定和奈沙地尔对兔水负荷性高眼压模型的作用比较。

目的：比较噻莫洛尔（β受体阻滞剂）、溴唑胺（碳酸酐酶抑制剂）、溴莫尼定（α2受体激动剂）和奈沙地尔（rho激酶抑制剂）对家兔眼压的降低作用。方法：选取52只雌性新西兰大白兔进行实验。测定正常血压家兔和水负荷性高眼压模型家兔的眼压。将30微升噻莫洛尔、溴唑胺、溴莫尼定、尼塔舒地尔或生理盐水局部施用于随机选择的眼睛。口服自来水60ml /kg诱导高眼压。结果：在正常血压家兔中，替莫洛尔、溴唑胺、溴胺定和奈沙地尔的最大降血压作用分别为2.9 mmHg （2 h）、5.2 mmHg （1 h）、5.7 mmHg （2 h）和3.3 mmHg （4 h）。在水负荷性高眼压模型家兔中，替马洛尔、布林唑胺、溴莫尼定和奈沙地尔的最大降眼压作用分别为3.6、5.0、12.2和5.0 mmHg。溴莫那定和奈沙地尔的降眼压作用持续到补水后90min。结论：替马洛尔、布林唑胺、溴莫尼定和奈沙地尔对正常血压家兔和水负荷性高眼压模型家兔均有降低眼压的作用。在高眼压兔模型中，促进房水流出的溴莫尼定和奈沙地尔比抑制房水产生的替马洛尔和布林唑胺表现出更强的降低眼压的作用。这些结果可以为每种药物的特征提供数据。这些数据可能有助于通过结合现有药物开发新的青光眼药物。

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来源期刊

Current Eye Research 医学-眼科学

CiteScore

4.60

自引率

0.00%

发文量

163

审稿时长

12 months

期刊介绍： The principal aim of Current Eye Research is to provide rapid publication of full papers, short communications and mini-reviews, all high quality. Current Eye Research publishes articles encompassing all the areas of eye research. Subject areas include the following: clinical research, anatomy, physiology, biophysics, biochemistry, pharmacology, developmental biology, microbiology and immunology.