The association between dyslipidemia and hand osteoarthritis: a systematic review and meta-analysis.

IF 2.9 3区医学 Q2 RHEUMATOLOGY

Clinical Rheumatology Pub Date : 2025-03-06 DOI:10.1007/s10067-025-07384-1

Tai-Yuan Hsueh, Yu-Pin Chen

{"title":"The association between dyslipidemia and hand osteoarthritis: a systematic review and meta-analysis.","authors":"Tai-Yuan Hsueh, Yu-Pin Chen","doi":"10.1007/s10067-025-07384-1","DOIUrl":null,"url":null,"abstract":"Background: Hand osteoarthritis (HOA) is a prevalent degenerative joint disease, with emerging evidence suggesting metabolic factors, including dyslipidemia, play a role in its pathogenesis. Dyslipidemia components, including low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglycerides, may contribute to cartilage damage and inflammation in hand joints, though robust evidence is limited.Method: A systematic review and meta-analysis were conducted using PubMed, Embase, and Web of Science to identify case-control and cohort studies examining the association between dyslipidemia and HOA. Dyslipidemia was assessed as a binary variable, while LDL, HDL, and triglycerides were analyzed as continuous variables. The quality of the included studies was assessed using the Newcastle-Ottawa Scale. Random effects model was used to calculate standardized mean differences (SMDs) and odds ratios (ORs). This study adhered to PRISMA guidelines for transparent reporting and was registered with the International Prospective Register of Systematic Reviews (CRD42024616873).Results: For dyslipidemia (binary), the pooled OR was 1.40 (95% CI = 1.19-1.66, P < 0.0001) with negligible heterogeneity (I2 = 0%, P = 0.82). Triglycerides showed a mean difference of 14.48 (95% CI = 5.37 to 23.60, P = 0.002) with low heterogeneity (I2 = 0%, P = 0.46). HDL yielded a pooled SMD of 0.48 (95% CI = - 1.50 to 2.46, P = 0.63) with low heterogeneity (I2 = 9%, P = 0.35). For LDL, the SMD was 4.78 (95% CI = - 0.53 to 10.09, P = 0.08) with moderate-to-high heterogeneity (I2 = 68%, P = 0.02).Conclusion: This meta-analysis reveals a moderate association between dyslipidemia, especially elevated triglycerides, and HOA. While lipid abnormalities may play a role in HOA development, the evidence for LDL and HDL is less clear. Limitations in study definitions and populations suggest the need for further research to better understand these relationships and their implications for prevention and management strategies in HOA.","PeriodicalId":10482,"journal":{"name":"Clinical Rheumatology","volume":" ","pages":""},"PeriodicalIF":2.9000,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Rheumatology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s10067-025-07384-1","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"RHEUMATOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Hand osteoarthritis (HOA) is a prevalent degenerative joint disease, with emerging evidence suggesting metabolic factors, including dyslipidemia, play a role in its pathogenesis. Dyslipidemia components, including low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglycerides, may contribute to cartilage damage and inflammation in hand joints, though robust evidence is limited.

Method: A systematic review and meta-analysis were conducted using PubMed, Embase, and Web of Science to identify case-control and cohort studies examining the association between dyslipidemia and HOA. Dyslipidemia was assessed as a binary variable, while LDL, HDL, and triglycerides were analyzed as continuous variables. The quality of the included studies was assessed using the Newcastle-Ottawa Scale. Random effects model was used to calculate standardized mean differences (SMDs) and odds ratios (ORs). This study adhered to PRISMA guidelines for transparent reporting and was registered with the International Prospective Register of Systematic Reviews (CRD42024616873).

Results: For dyslipidemia (binary), the pooled OR was 1.40 (95% CI = 1.19-1.66, P < 0.0001) with negligible heterogeneity (I² = 0%, P = 0.82). Triglycerides showed a mean difference of 14.48 (95% CI = 5.37 to 23.60, P = 0.002) with low heterogeneity (I² = 0%, P = 0.46). HDL yielded a pooled SMD of 0.48 (95% CI = - 1.50 to 2.46, P = 0.63) with low heterogeneity (I² = 9%, P = 0.35). For LDL, the SMD was 4.78 (95% CI = - 0.53 to 10.09, P = 0.08) with moderate-to-high heterogeneity (I² = 68%, P = 0.02).

Conclusion: This meta-analysis reveals a moderate association between dyslipidemia, especially elevated triglycerides, and HOA. While lipid abnormalities may play a role in HOA development, the evidence for LDL and HDL is less clear. Limitations in study definitions and populations suggest the need for further research to better understand these relationships and their implications for prevention and management strategies in HOA.

查看原文本刊更多论文

血脂异常与手骨关节炎的关系：一项系统综述和荟萃分析。

背景：手骨关节炎（HOA）是一种常见的退行性关节疾病，越来越多的证据表明代谢因素，包括血脂异常，在其发病机制中起作用。血脂异常成分，包括低密度脂蛋白（LDL）、高密度脂蛋白（HDL）和甘油三酯，可能导致手关节软骨损伤和炎症，尽管有力的证据有限。方法：使用PubMed、Embase和Web of Science进行系统回顾和荟萃分析，以确定检查血脂异常与HOA之间关系的病例对照和队列研究。血脂异常被评估为二元变量，而LDL、HDL和甘油三酯被分析为连续变量。纳入研究的质量采用纽卡斯尔-渥太华量表进行评估。采用随机效应模型计算标准化平均差（SMDs）和比值比（ORs）。本研究遵循PRISMA透明报告指南，并在国际前瞻性系统评价注册（CRD42024616873）注册。结果：对于血脂异常（二元），合并OR为1.40 （95% CI = 1.19-1.66, P 2 = 0%, P = 0.82）。甘油三酯的平均差异为14.48 (95% CI = 5.37 ~ 23.60, P = 0.002)，异质性较低（I2 = 0%, P = 0.46）。HDL产生的汇总SMD为0.48 (95% CI = - 1.50至2.46,P = 0.63)，异质性低（I2 = 9%, P = 0.35）。LDL的SMD为4.78 (95% CI = - 0.53 ~ 10.09, P = 0.08)，具有中高异质性（I2 = 68%, P = 0.02）。结论：这项荟萃分析揭示了血脂异常，特别是甘油三酯升高与HOA之间的中度关联。虽然脂质异常可能在HOA的发展中起作用，但LDL和HDL的证据不太清楚。研究定义和人群的局限性表明，需要进一步研究以更好地了解这些关系及其对HOA预防和管理策略的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Clinical Rheumatology 医学-风湿病学

CiteScore

6.90

自引率

2.90%

发文量

441

审稿时长

3 months

期刊介绍： Clinical Rheumatology is an international English-language journal devoted to publishing original clinical investigation and research in the general field of rheumatology with accent on clinical aspects at postgraduate level. The journal succeeds Acta Rheumatologica Belgica, originally founded in 1945 as the official journal of the Belgian Rheumatology Society. Clinical Rheumatology aims to cover all modern trends in clinical and experimental research as well as the management and evaluation of diagnostic and treatment procedures connected with the inflammatory, immunologic, metabolic, genetic and degenerative soft and hard connective tissue diseases.