Bidirectional association between sarcopenia and diabetes: A prospective cohort study in middle-aged and elderly adults

IF 2.9 Q3 NUTRITION & DIETETICS

Clinical nutrition ESPEN Pub Date : 2025-03-03 DOI:10.1016/j.clnesp.2025.02.026

Yu Zhang, Miao Gong, Xu-Man Feng, Yu-Xiang Yan

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引用次数: 0

Abstract

Background and aims

Sarcopenia and diabetes are prevalent diseases among middle-aged and elderly population. This study aimed to investigate the bidirectional association between sarcopenia and diabetes.

Methods

This study comprised two longitudinal analyses. In cohort 1, the association between baseline diabetes and the risk of new-onset sarcopenia was assessed. In cohort 2, the association between baseline sarcopenia and the risk of new-onset diabetes was examined. Multivariate logistic regression models were used to calculate odds ratios (OR) and 95 % confidence intervals (95 % CI). Cross-lagged panel analysis was used to further validate their bidirectional associations.

Results

Significant bidirectional associations were observed between sarcopenia and diabetes in both cross-sectional and longitudinal analyses (P < 0.05). After four years of follow-up, low handgrip strength (OR: 2.31, 95 % CI: 1.74–3.08) and appendicular skeletal muscle mass index (ASM/Ht²) (OR: 1.25, 95 % CI: 1.20–1.30) were associated with an increased risk of diabetes. Conversely, elevated fasting plasma glucose (FPG) (OR: 1.52, 95 % CI: 1.17–1.96) and glycated hemoglobin A_1c (HbA_1c) (OR: 1.35, 95 % CI: 1.05–1.73) were associated with a higher risk of sarcopenia. Cross-lagged analysis further confirmed their bidirectional longitudinal association.

Conclusions

This study identified significant longitudinal bidirectional association between sarcopenia and diabetes, highlighting that each condition serves as a risk factor for the other. Clinically, early assessments of handgrip strength and ASM/Ht² may aid in diabetes prevention, while monitoring FPG and HbA_1c could help reduce the risk of sarcopenia.

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肌肉减少症与糖尿病之间的双向关联：一项针对中老年人的前瞻性队列研究。

背景与目的：肌肉减少症和糖尿病是中老年人群的常见病。本研究旨在探讨肌肉减少症与糖尿病之间的双向关系。方法：本研究包括两项纵向分析。在队列1中，评估了基线糖尿病与新发肌肉减少症风险之间的关系。在队列2中，研究了基线肌减少症与新发糖尿病风险之间的关系。采用多变量logistic回归模型计算优势比（OR）和95%置信区间（95% CI）。交叉滞后面板分析用于进一步验证其双向关联。结果：在横断面和纵向分析中，肌肉减少症与糖尿病之间存在显著的双向关联（P < 0.05）。经过四年的随访，低握力（OR: 2.31, 95% CI: 1.74-3.08）和阑尾骨骼肌质量指数（ASM/Ht2）（OR: 1.25, 95% CI: 1.20-1.30）与糖尿病风险增加相关。相反，空腹血糖（FPG）（OR: 1.52, 95% CI: 1.17-1.96）和糖化血红蛋白（HbA1c）（OR: 1.35, 95% CI: 1.05-1.73）升高与肌肉减少症的高风险相关。交叉滞后分析进一步证实了它们的双向纵向关联。结论：本研究确定了肌肉减少症和糖尿病之间显著的纵向双向关联，强调每一种情况都是另一种情况的危险因素。在临床上，早期评估握力和ASM/Ht2可能有助于预防糖尿病，而监测FPG和HbA1c可能有助于降低肌肉减少症的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical nutrition ESPEN NUTRITION & DIETETICS-

CiteScore

4.90

自引率

3.30%

发文量

512

期刊介绍： Clinical Nutrition ESPEN is an electronic-only journal and is an official publication of the European Society for Clinical Nutrition and Metabolism (ESPEN). Nutrition and nutritional care have gained wide clinical and scientific interest during the past decades. The increasing knowledge of metabolic disturbances and nutritional assessment in chronic and acute diseases has stimulated rapid advances in design, development and clinical application of nutritional support. The aims of ESPEN are to encourage the rapid diffusion of knowledge and its application in the field of clinical nutrition and metabolism. Published bimonthly, Clinical Nutrition ESPEN focuses on publishing articles on the relationship between nutrition and disease in the setting of basic science and clinical practice. Clinical Nutrition ESPEN is available to all members of ESPEN and to all subscribers of Clinical Nutrition.