Effects of cerebellar non-invasive brain stimulation on balance and gait performance in individuals with stroke: a systematic review and meta-analysis.

IF 3.4 3区 医学 Q1 REHABILITATION
Jiaxin Jiang, Yawen Chen, Florence S Fan, Qiang Gao, Brenton Hordacre, Margaret K Mak, Meizhen Huang
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引用次数: 0

Abstract

Introduction: Non-invasive brain stimulation (NIBS) is widely used for motor recovery after stroke. Recent studies have investigated the efficacy of cerebellar NIBS (cNIBS) in enhancing lower limb functional recovery in individuals with stroke. Thus, this study aims to investigate the effect of cNIBS on balance and gait recovery in individuals with stroke.

Evidence acquisition: A systematic literature search was conducted in CINAHL, Cochrane Library, MEDLINE, Physiotherapy Evidence Database, PsyclNFO, PubMed, and Scopus from inception to April 29, 2024. Randomized controlled trials (RCTs) that investigated the effects of cNIBS on gait or balance performance in individuals with stroke were included. Studies involving participants with cerebellar or brainstem stroke were excluded. Two researchers independently conducted study selection and data extraction and examined the methodological quality of the included RCTs and the certainty of evidence. A random-effects meta-analysis was performed to estimate the between-group mean difference (MD) or standardized MD (SMD) based on pre-post changes along with the 95% confidence interval (CI).

Evidence synthesis: Fourteen RCTs involving 382 participants were included. The methodological quality of the included studies ranged from fair to excellent. Compared with sham conditions, cNIBS significantly improved balance, as measured using the Berg Balance Scale (MD=4.17, 95% CI=2.28-6.05, P<0.01, low certainty of evidence); walking speed, as assessed using the 10-m walk test and 25-Feet Walk Test (SMD=-0.36, 95% CI=-0.68 to -0.03, P=0.03, moderate certainty of evidence); and functional mobility, as measured using the Timed Up and Go test (MD: -3.34, 95% CI=-5.14 to -1.54, P<0.01, low certainty of evidence).

Conclusions: With low-to-moderate certainty, the evidence indicates that cNIBS, including tDCS and TMS, can improve balance in individuals with stroke. cNIBS is also a promising approach to facilitate gait and functional mobility in stroke survivors. Future studies should determine optimal stimulation protocols and elucidate the mechanisms underlying the treatment effects.

小脑非侵入性脑刺激对中风患者平衡和步态表现的影响:一项系统回顾和荟萃分析。
无创脑刺激(NIBS)被广泛应用于脑卒中后的运动恢复。最近的研究调查了小脑NIBS (cNIBS)对脑卒中患者下肢功能恢复的促进作用。因此,本研究旨在探讨cNIBS对脑卒中患者平衡和步态恢复的影响。证据获取:系统检索CINAHL、Cochrane Library、MEDLINE、Physiotherapy Evidence Database、PsyclNFO、PubMed和Scopus,检索时间为创刊至2024年4月29日。随机对照试验(RCTs)研究了cNIBS对中风患者步态或平衡能力的影响。涉及小脑或脑干中风受试者的研究被排除在外。两名研究人员独立进行了研究选择和数据提取,并检查了纳入的随机对照试验的方法学质量和证据的确定性。进行随机效应荟萃分析,根据前后变化和95%置信区间(CI)估计组间平均差异(MD)或标准化MD (SMD)。证据综合:纳入14项随机对照试验,涉及382名受试者。纳入研究的方法学质量从一般到优秀不等。用Berg平衡量表测量,与假手术相比,cNIBS显著改善了平衡(MD=4.17, 95% CI=2.28-6.05)。结论:有低至中等确定性的证据表明,cNIBS,包括tDCS和TMS,可以改善脑卒中患者的平衡。cNIBS也是一种很有前途的方法,可以促进中风幸存者的步态和功能活动。未来的研究应该确定最佳的刺激方案,并阐明治疗效果的机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
8.50
自引率
4.40%
发文量
162
审稿时长
6-12 weeks
期刊介绍: The European Journal of Physical and Rehabilitation Medicine publishes papers of clinical interest in physical and rehabilitation medicine.
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