{"title":"AI-based biplane X-ray image-guided method for distal radius fracture reduction.","authors":"Qing Zha, Sizhou Shen, Ziyang Ma, Manqiu Yu, Hongzheng Bi, Hongbo Yang","doi":"10.3389/fbioe.2025.1502669","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>In the course of manual reduction of distal radius fractures, many doctors rely on tactile perception to assess the displacement of the fracture. However, a more accurate determination of the severity of the fracture and the success of the reduction requires measurement software to annotate the fracture images, which is difficult to achieve real-timely in actual procedure of reduction. Which may lead to misdiagnosis when experienced doctors rely on their intuition. Therefore, it is necessary to develop an AI-based method for calculating fracture parameters to provide real-time display, particularly in fracture reduction machines.</p><p><strong>Methods: </strong>An AI-based method for automatically calculating of radiographic parameters in distal radius fractures (DRF) was developed. Initially, anteroposterior (AP) and lateral (LAT) X-ray images of patients with distal radius fractures were collected from three hospitals and preprocessed. Subsequently, several neural network structures, UNet, DeeplabV3+, PSPNet, and TransUNet, are compared in terms of utility and accuracy, and finally, the models obtained from the UNet image segmentation algorithm are used for semantic segmentation of the radius and ulna. Following this, the contours of the radius and ulna were extracted using OpenCV, key points were detected, and the principal axes were calculated. Finally, the computed parameters including radial angle (RA), radial length (RL), ulnar variance (UV), and palmar tilt (PT) were calculated and displayed on the image.</p><p><strong>Results: </strong>The advantages and disadvantages of several models were considered, and finally the UNet neural network model was used as the core algorithm of the image segmentation model in this study. The segmentation accuracy for the radius and ulna in the AP and LAT X-ray images reached 91.31% and 88.63%, respectively. The average errors between the automated calculations of parameters RA, RL, UV, and PT and the manually annotated results by physicians were -1.36°, -1.7 mm, 0.66 mm, and -1.06°, respectively. The system has been initially deployed on the same computer that operates the radial fracture fracture repositioning robot.</p><p><strong>Conclusion: </strong>The automated parameter calculation method developed in this study accurately computes diagnostic parameters for assessing distal radius fractures and can be utilized in the image-guided reduction process of fracture rehabilitation robots. This method has the potential to evolve into an intelligent diagnostic tool for physicians, thereby enhancing the accuracy of distal radius fracture diagnosis.</p>","PeriodicalId":12444,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 ","pages":"1502669"},"PeriodicalIF":4.3000,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11880290/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Bioengineering and Biotechnology","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.3389/fbioe.2025.1502669","RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background: In the course of manual reduction of distal radius fractures, many doctors rely on tactile perception to assess the displacement of the fracture. However, a more accurate determination of the severity of the fracture and the success of the reduction requires measurement software to annotate the fracture images, which is difficult to achieve real-timely in actual procedure of reduction. Which may lead to misdiagnosis when experienced doctors rely on their intuition. Therefore, it is necessary to develop an AI-based method for calculating fracture parameters to provide real-time display, particularly in fracture reduction machines.
Methods: An AI-based method for automatically calculating of radiographic parameters in distal radius fractures (DRF) was developed. Initially, anteroposterior (AP) and lateral (LAT) X-ray images of patients with distal radius fractures were collected from three hospitals and preprocessed. Subsequently, several neural network structures, UNet, DeeplabV3+, PSPNet, and TransUNet, are compared in terms of utility and accuracy, and finally, the models obtained from the UNet image segmentation algorithm are used for semantic segmentation of the radius and ulna. Following this, the contours of the radius and ulna were extracted using OpenCV, key points were detected, and the principal axes were calculated. Finally, the computed parameters including radial angle (RA), radial length (RL), ulnar variance (UV), and palmar tilt (PT) were calculated and displayed on the image.
Results: The advantages and disadvantages of several models were considered, and finally the UNet neural network model was used as the core algorithm of the image segmentation model in this study. The segmentation accuracy for the radius and ulna in the AP and LAT X-ray images reached 91.31% and 88.63%, respectively. The average errors between the automated calculations of parameters RA, RL, UV, and PT and the manually annotated results by physicians were -1.36°, -1.7 mm, 0.66 mm, and -1.06°, respectively. The system has been initially deployed on the same computer that operates the radial fracture fracture repositioning robot.
Conclusion: The automated parameter calculation method developed in this study accurately computes diagnostic parameters for assessing distal radius fractures and can be utilized in the image-guided reduction process of fracture rehabilitation robots. This method has the potential to evolve into an intelligent diagnostic tool for physicians, thereby enhancing the accuracy of distal radius fracture diagnosis.
期刊介绍:
The translation of new discoveries in medicine to clinical routine has never been easy. During the second half of the last century, thanks to the progress in chemistry, biochemistry and pharmacology, we have seen the development and the application of a large number of drugs and devices aimed at the treatment of symptoms, blocking unwanted pathways and, in the case of infectious diseases, fighting the micro-organisms responsible. However, we are facing, today, a dramatic change in the therapeutic approach to pathologies and diseases. Indeed, the challenge of the present and the next decade is to fully restore the physiological status of the diseased organism and to completely regenerate tissue and organs when they are so seriously affected that treatments cannot be limited to the repression of symptoms or to the repair of damage. This is being made possible thanks to the major developments made in basic cell and molecular biology, including stem cell science, growth factor delivery, gene isolation and transfection, the advances in bioengineering and nanotechnology, including development of new biomaterials, biofabrication technologies and use of bioreactors, and the big improvements in diagnostic tools and imaging of cells, tissues and organs.
In today`s world, an enhancement of communication between multidisciplinary experts, together with the promotion of joint projects and close collaborations among scientists, engineers, industry people, regulatory agencies and physicians are absolute requirements for the success of any attempt to develop and clinically apply a new biological therapy or an innovative device involving the collective use of biomaterials, cells and/or bioactive molecules. “Frontiers in Bioengineering and Biotechnology” aspires to be a forum for all people involved in the process by bridging the gap too often existing between a discovery in the basic sciences and its clinical application.