Intestinal Luminal Anion Transporters and their Interplay with Gut Microbiome and Inflammation.

IF 5 2区 生物学 Q2 CELL BIOLOGY
Nazim Husain, Anoop Kumar, Arivarasu N Anbazhagan, Ravinder K Gill, Pradeep K Dudeja
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引用次数: 0

Abstract

The intestine, as a critical interface between the external environment and the internal body, plays a central role in nutrient absorption, immune regulation, and maintaining homeostasis. The intestinal epithelium, composed of specialized epithelial cells, hosts apical anion transporters that primarily mediate the transport of chloride and bicarbonate ions, essential for maintaining electrolyte balance, pH homeostasis, and fluid absorption/secretion. Additionally, the intestine hosts a diverse population of gut microbiota that plays a pivotal role in various physiological processes including nutrient metabolism, immune regulation and maintenance of intestinal barrier integrity, all of which are critical for host gut homeostasis and health. The anion transporters and gut microbiome are intricately interconnected, where alterations in one can trigger changes in the other leading to compromised barrier integrity and increasing susceptibility to pathophysiological states including gut inflammation. This review focuses on the interplay of key apical anion transporters including Down Regulated in Adenoma (DRA, SLC26A3), Putative Anion Transporter-1 (PAT1, SLC26A6) and Cystic Fibrosis Transmembrane Conductance Regulator (CFTR, ABCC7) with the gut microbiome, barrier integrity and their relationship to gut inflammation.

肠腔阴离子转运体及其与肠道微生物群和炎症的相互作用。
肠道作为连接机体内外环境的重要接口,在营养吸收、免疫调节和维持体内平衡等方面发挥着重要作用。肠上皮由特化上皮细胞组成,承载着主要介导氯离子和碳酸氢盐离子运输的根尖阴离子转运体,对维持电解质平衡、pH稳态和液体吸收/分泌至关重要。此外,肠道拥有多样化的肠道微生物群,在各种生理过程中发挥关键作用,包括营养代谢、免疫调节和肠道屏障完整性的维持,所有这些都对宿主肠道稳态和健康至关重要。阴离子转运体和肠道微生物群是错综复杂的相互联系,其中一个的改变会引发另一个的变化,导致屏障完整性受损,并增加对包括肠道炎症在内的病理生理状态的易感性。本文综述了腺瘤中的下调阴离子转运蛋白(Down Regulated in Adenoma, DRA, SLC26A3)、推测阴离子转运蛋白-1 (Putative anion Transporter-1, PAT1, SLC26A6)和囊性纤维化跨膜传导调节蛋白(CFTR, ABCC7)等关键根顶阴离子转运蛋白与肠道微生物群、屏障完整性及其与肠道炎症的关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
9.10
自引率
1.80%
发文量
252
审稿时长
1 months
期刊介绍: The American Journal of Physiology-Cell Physiology is dedicated to innovative approaches to the study of cell and molecular physiology. Contributions that use cellular and molecular approaches to shed light on mechanisms of physiological control at higher levels of organization also appear regularly. Manuscripts dealing with the structure and function of cell membranes, contractile systems, cellular organelles, and membrane channels, transporters, and pumps are encouraged. Studies dealing with integrated regulation of cellular function, including mechanisms of signal transduction, development, gene expression, cell-to-cell interactions, and the cell physiology of pathophysiological states, are also eagerly sought. Interdisciplinary studies that apply the approaches of biochemistry, biophysics, molecular biology, morphology, and immunology to the determination of new principles in cell physiology are especially welcome.
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