Histological characterization of the inferior vena cava in cases of duplicated inferior vena cava.

IF 1.2 4区 医学 Q3 ANATOMY & MORPHOLOGY
Shintaro Fujimura, Takuya Omotehara, Shiori Yoshimura, Shinichi Kawata, Masahiro Itoh
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Abstract

Duplicated inferior vena cava (DIVC) is a congenital anomaly where the inferior vena cava (IVC) is present on either side of the abdominal aorta. Previous studies have noted smaller IVC widths in DIVC cases, but detailed structural characteristics remain unclear. This study aimed to characterize the histological structure of the IVC in DIVC and normal cases. Histological analysis was performed on the IVC just below the liver (IVC-Liver), the IVC at the 4th lumbar vertebra level (IVC-L4), and the external iliac vein (EIV) from donated cadavers. The tissues underwent HE staining and immunohistochemistry to detect elastin and alpha smooth muscle actin, with the cross-sectional area of vessel lumina and immunopositive area calculated. The study found that the combined cross-sectional areas of the right and left IVC-L4 in DIVC cases were smaller than the single IVC-L4 area in normal cases. Histologically, DIVC cases showed a significantly decreased ratio of elastin immunopositive areas, compared to normal cases. This reduction in cross-sectional areas and elastin ratio suggests that IVCs in DIVC cases hold less blood volume and have weaker contractility by elastic fibers after dilation, potentially leading to disrupted blood circulation in the lower body.

重复下腔静脉病例下腔静脉的组织学特征。
重复下腔静脉(DIVC)是一种先天性异常,下腔静脉(IVC)存在于腹主动脉的两侧。先前的研究指出,DIVC病例的下腔静脉宽度较小,但详细的结构特征尚不清楚。本研究旨在描述DIVC和正常病例下腔静脉的组织学结构。对捐献尸体的肝下IVC (IVC- liver)、第4腰椎段IVC- l4和髂外静脉(EIV)进行组织学分析。组织行HE染色和免疫组化检测弹性蛋白和α平滑肌肌动蛋白,计算血管腔截面积和免疫阳性面积。研究发现,DIVC患者左右下腔静脉- l4的联合横截面积小于正常患者的单个下腔静脉- l4面积。组织学上,与正常病例相比,DIVC病例弹性蛋白免疫阳性区比例明显降低。这种横截面积和弹性蛋白比的减少表明,DIVC患者的静脉内腔容量更少,扩张后弹性纤维的收缩能力更弱,可能导致下体血液循环中断。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Anatomical Science International
Anatomical Science International 医学-解剖学与形态学
CiteScore
2.80
自引率
8.30%
发文量
50
审稿时长
>12 weeks
期刊介绍: The official English journal of the Japanese Association of Anatomists, Anatomical Science International (formerly titled Kaibogaku Zasshi) publishes original research articles dealing with morphological sciences. Coverage in the journal includes molecular, cellular, histological and gross anatomical studies on humans and on normal and experimental animals, as well as functional morphological, biochemical, physiological and behavioral studies if they include morphological analysis.
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