{"title":"Histological characterization of the inferior vena cava in cases of duplicated inferior vena cava.","authors":"Shintaro Fujimura, Takuya Omotehara, Shiori Yoshimura, Shinichi Kawata, Masahiro Itoh","doi":"10.1007/s12565-025-00830-9","DOIUrl":null,"url":null,"abstract":"<p><p>Duplicated inferior vena cava (DIVC) is a congenital anomaly where the inferior vena cava (IVC) is present on either side of the abdominal aorta. Previous studies have noted smaller IVC widths in DIVC cases, but detailed structural characteristics remain unclear. This study aimed to characterize the histological structure of the IVC in DIVC and normal cases. Histological analysis was performed on the IVC just below the liver (IVC-Liver), the IVC at the 4th lumbar vertebra level (IVC-L4), and the external iliac vein (EIV) from donated cadavers. The tissues underwent HE staining and immunohistochemistry to detect elastin and alpha smooth muscle actin, with the cross-sectional area of vessel lumina and immunopositive area calculated. The study found that the combined cross-sectional areas of the right and left IVC-L4 in DIVC cases were smaller than the single IVC-L4 area in normal cases. Histologically, DIVC cases showed a significantly decreased ratio of elastin immunopositive areas, compared to normal cases. This reduction in cross-sectional areas and elastin ratio suggests that IVCs in DIVC cases hold less blood volume and have weaker contractility by elastic fibers after dilation, potentially leading to disrupted blood circulation in the lower body.</p>","PeriodicalId":7816,"journal":{"name":"Anatomical Science International","volume":" ","pages":""},"PeriodicalIF":1.2000,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Anatomical Science International","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s12565-025-00830-9","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ANATOMY & MORPHOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Duplicated inferior vena cava (DIVC) is a congenital anomaly where the inferior vena cava (IVC) is present on either side of the abdominal aorta. Previous studies have noted smaller IVC widths in DIVC cases, but detailed structural characteristics remain unclear. This study aimed to characterize the histological structure of the IVC in DIVC and normal cases. Histological analysis was performed on the IVC just below the liver (IVC-Liver), the IVC at the 4th lumbar vertebra level (IVC-L4), and the external iliac vein (EIV) from donated cadavers. The tissues underwent HE staining and immunohistochemistry to detect elastin and alpha smooth muscle actin, with the cross-sectional area of vessel lumina and immunopositive area calculated. The study found that the combined cross-sectional areas of the right and left IVC-L4 in DIVC cases were smaller than the single IVC-L4 area in normal cases. Histologically, DIVC cases showed a significantly decreased ratio of elastin immunopositive areas, compared to normal cases. This reduction in cross-sectional areas and elastin ratio suggests that IVCs in DIVC cases hold less blood volume and have weaker contractility by elastic fibers after dilation, potentially leading to disrupted blood circulation in the lower body.
期刊介绍:
The official English journal of the Japanese Association of Anatomists, Anatomical Science International (formerly titled Kaibogaku Zasshi) publishes original research articles dealing with morphological sciences.
Coverage in the journal includes molecular, cellular, histological and gross anatomical studies on humans and on normal and experimental animals, as well as functional morphological, biochemical, physiological and behavioral studies if they include morphological analysis.