{"title":"Prospects for applying radioactive ion beams in particle therapy","authors":"Taiga Yamaya, Han Gyu Kang, Akram Hamato, Chie Toramatsu, Taku Inaniwa","doi":"10.1140/epjp/s13360-025-06039-z","DOIUrl":null,"url":null,"abstract":"<div><p>Particle beam therapy is becoming increasingly popular as an advanced cancer treatment method, and currently proton and (stable) carbon ion beams are used clinically. Recently, in-beam positron emission tomography (PET) has been investigated for dose monitoring technique during particle therapy. However, the signal-to-noise ratio of in-beam PET images is poor due to the low yield of positron emitters. On the contrary, radioactive ion (RI) beams is ideally suited to particle therapy using in-beam PET due to its high signal-to-noise ratio. In addition, RI beams enable more accurate analysis of the biological washout effect than conventional stable beam irradiations do. These advantages have been clearly demonstrated in many animal studies with prototyped PET systems. On the other hand, there are several issues that limit clinical use of RI beams such as the low RI beam intensity, large momentum distribution, and the limited number of RI beam facilities. This article reviews the state-of-the-art research and development for applications of RI beams to particle beam therapy.</p></div>","PeriodicalId":792,"journal":{"name":"The European Physical Journal Plus","volume":"140 3","pages":""},"PeriodicalIF":2.8000,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The European Physical Journal Plus","FirstCategoryId":"4","ListUrlMain":"https://link.springer.com/article/10.1140/epjp/s13360-025-06039-z","RegionNum":3,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PHYSICS, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Particle beam therapy is becoming increasingly popular as an advanced cancer treatment method, and currently proton and (stable) carbon ion beams are used clinically. Recently, in-beam positron emission tomography (PET) has been investigated for dose monitoring technique during particle therapy. However, the signal-to-noise ratio of in-beam PET images is poor due to the low yield of positron emitters. On the contrary, radioactive ion (RI) beams is ideally suited to particle therapy using in-beam PET due to its high signal-to-noise ratio. In addition, RI beams enable more accurate analysis of the biological washout effect than conventional stable beam irradiations do. These advantages have been clearly demonstrated in many animal studies with prototyped PET systems. On the other hand, there are several issues that limit clinical use of RI beams such as the low RI beam intensity, large momentum distribution, and the limited number of RI beam facilities. This article reviews the state-of-the-art research and development for applications of RI beams to particle beam therapy.
期刊介绍：
The aims of this peer-reviewed online journal are to distribute and archive all relevant material required to document, assess, validate and reconstruct in detail the body of knowledge in the physical and related sciences.
The scope of EPJ Plus encompasses a broad landscape of fields and disciplines in the physical and related sciences - such as covered by the topical EPJ journals and with the explicit addition of geophysics, astrophysics, general relativity and cosmology, mathematical and quantum physics, classical and fluid mechanics, accelerator and medical physics, as well as physics techniques applied to any other topics, including energy, environment and cultural heritage.
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