Genetically distinct Hajj and South American-related strains of serogroup W Neisseria meningitidis causing invasive meningococcal disease in Ontario, Canada, January 1, 2015 to June 30, 2024

IF 4.7 3区医学 Q1 INFECTIOUS DISEASES

Journal of Infection and Public Health Pub Date : 2025-03-01 DOI:10.1016/j.jiph.2025.102728

Courtney Meilleur , Julianne Kus , Christine Navarro , Vinita Dubey , Jay Lucidarme , Ray Borrow , Raymond S.W. Tsang

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引用次数: 0

Abstract

Objectives

To characterize the recent trends in serogroup W isolates from invasive meningococcal disease (IMD) cases (MenW) in Ontario, Canada since 2015.

Methods

IMD case isolates in Ontario between January 1, 2015 and June 30, 2024 were examined by phenotypic and genetic methods for possession of vaccine antigen genes and clonal characteristics. MenW ST-11 clonal complex (CC) strains were compared against global MenW isolates by core-genome multi-locus sequence typing (cgMLST).

Results

The percentage of culture-confirmed IMD caused by MenW in Ontario increased from 10 % in 2015–40.9 % in the first half of 2024, consisting entirely of strains belonging to the ST-11 CC. cgMLST comparison of the Ontario invasive MenW isolates versus international MenW ST-11CC strains showed that the Ontario isolates were related to those found globally, with a recent cluster of eight cases from one city due to a strain highly related to international Umrah outbreak strains. Most MenW IMD cases (60 %) occurred in individuals older than 40 years of age and the majority (83.3 %) predicted to express antigens covered by the 4CMenB vaccine.

Conclusions

Multiple different introductions of international MenW strains likely accounted for the recent shift towards invasive MenW disease in Ontario.

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2015年1月1日至2024年6月30日在加拿大安大略省引起侵袭性脑膜炎球菌病的W血清群脑膜炎奈瑟菌的基因不同的朝觐和南美相关菌株

目的了解加拿大安大略省自2015年以来侵袭性脑膜炎球菌病（IMD）病例（MenW）血清W群分离物的最新趋势。方法对2015年1月1日至2024年6月30日在安大略省分离的simd病例进行表型和遗传分析，分析其疫苗抗原基因及克隆特征。采用核心基因组多位点序列分型（cgMLST）对MenW ST-11克隆复合体（CC）菌株与全球MenW分离株进行比较。结果安大略省由MenW引起的培养确诊IMD的百分比从2015年的10 %上升到2024年上半年的40.9 %，完全由ST-11 cc的菌株组成。安大略省入侵性MenW分离株与国际MenW ST-11CC株的cgMLST比较显示，安大略省分离株与全球发现的MenW分离株有关，最近一个城市的8例聚集性病例是由于与国际朝觐暴发株高度相关的菌株。大多数MenW IMD病例（60 %）发生在40岁以上的个体中，大多数（83.3 %）预测表达4CMenB疫苗覆盖的抗原。结论多种不同的国际MenW菌株的引入可能是最近安大略省向侵袭性MenW疾病转变的原因。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Infection and Public Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH -INFECTIOUS DISEASES

CiteScore

13.10

自引率

1.50%

发文量

203

审稿时长

96 days

期刊介绍： The Journal of Infection and Public Health, first official journal of the Saudi Arabian Ministry of National Guard Health Affairs, King Saud Bin Abdulaziz University for Health Sciences and the Saudi Association for Public Health, aims to be the foremost scientific, peer-reviewed journal encompassing infection prevention and control, microbiology, infectious diseases, public health and the application of healthcare epidemiology to the evaluation of health outcomes. The point of view of the journal is that infection and public health are closely intertwined and that advances in one area will have positive consequences on the other. The journal will be useful to all health professionals who are partners in the management of patients with communicable diseases, keeping them up to date. The journal is proud to have an international and diverse editorial board that will assist and facilitate the publication of articles that reflect a global view on infection control and public health, as well as emphasizing our focus on supporting the needs of public health practitioners. It is our aim to improve healthcare by reducing risk of infection and related adverse outcomes by critical review, selection, and dissemination of new and relevant information in the field of infection control, public health and infectious diseases in all healthcare settings and the community.