Efficacy of mesenchymal stem cell transplantation therapy to mitigate psoriasis: A systematic review and meta-analysis

IF 3.2 4区 医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL
Rahul Dey , Amitava Das
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引用次数: 0

Abstract

Psoriasis is a chronic inflammatory skin disease characterized by red lesions and skin patches with silvery scales. Overall, 2 - 3 % of the worldwide population is affected by psoriasis. Recent treatment strategies for psoriasis involve Mesenchymal stromal/stem cell (MSC) transplantation instead of conventional treatment with monoclonal antibodies and small molecule drugs. However, studies systematically determining the efficacy of MSC therapy to treat psoriasis are lacking. Three electronic databases, including Cochrane, PubMed, and Web of Science Library, were searched for related studies from 2013 to 2023 using a widespread list of key terms. Among the collected records, duplicates and non-relevant articles were removed by screening the title, abstract, and full text based on the inclusion and exclusion criteria. Data were extracted from the eligible full-text articles to perform the meta-analysis, determining MSC therapy's efficacy in treating psoriasis. In the screening process, five clinical and sixteen preclinical studies, including 1 study with both preclinical and clinical data, showing the efficacy of MSC transplantation therapy to mitigate psoriasis were eligible for the systematic review. The meta-analysis was based on the data extracted from 10 eligible preclinical studies involving 343 animals. Pooled results demonstrated that the Psoriasis Area and Severity Index (PASI) score and the epidermal thickness of the psoriatic plaques in the animals post-MSC transplantation were significantly reduced. Our meta-analysis showed the efficacy of MSC transplantation therapies in mitigating psoriasis in preclinical animal models. Thus, further clinical research is warranted to translate these findings from bench to bedside.
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来源期刊
Current Research in Translational Medicine
Current Research in Translational Medicine Biochemistry, Genetics and Molecular Biology-General Biochemistry,Genetics and Molecular Biology
CiteScore
7.00
自引率
4.90%
发文量
51
审稿时长
45 days
期刊介绍: Current Research in Translational Medicine is a peer-reviewed journal, publishing worldwide clinical and basic research in the field of hematology, immunology, infectiology, hematopoietic cell transplantation, and cellular and gene therapy. The journal considers for publication English-language editorials, original articles, reviews, and short reports including case-reports. Contributions are intended to draw attention to experimental medicine and translational research. Current Research in Translational Medicine periodically publishes thematic issues and is indexed in all major international databases (2017 Impact Factor is 1.9). Core areas covered in Current Research in Translational Medicine are: Hematology, Immunology, Infectiology, Hematopoietic, Cell Transplantation, Cellular and Gene Therapy.
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