Antimicrobial diterpenoids from Rosmarinus officinalis

IF 2.1 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Steroids Pub Date : 2025-03-03 DOI:10.1016/j.steroids.2025.109589

Qing-Jiang Xu , Jia-Chen Liu , Jia Xu , Xin Wang , Xiao-Ya Shang , Jiachen Zi

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引用次数: 0

Abstract

Three new diterpenoids, 12,16-epoxy-11-hydroxy-17(15 → 16)-abeo-abieta-8,11,13-trien-7-one (1), 7,12-dihydroxy abieta-6,8,10(5),11,13-quien-20-oic acid 1,20-lactone (2), labda-5(10),13(E)-dien-15-ol (11), one new natural product (2E,6E)-3,7-dimethyl-9-[(1S,6R)-1,2,6-trimethylcyclohex-2-enyl]nona-2,6-dien-1-ol (16) and thirteen known compounds were isolated and elucidated from the excellent antimicrobial active fractions of Rosmarinus officinalis ethanol extract. The structures of the isolated compounds were determined by spectral data analysis and combined with literature reports. Among them, monocyclic diterpenoids (16 and 17) were discovered from rosemary for the first time. All isolated compounds were tested for antimicrobial activity against four strains (B. subtilis, S. aureus, P. aeruginosa, and Fusarium spp.), with six compounds showing very strong inhibitory activity against B. subtilis and four compounds showing strong inhibitory activity against P. aeruginosa.

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迷迭香抗菌二萜

三个新的二萜12 16-epoxy-11-hydroxy-17 -abeo-abieta-8(15→16),11日13-trien-7-one(1), 7日12-dihydroxy abieta-6, 8、10(5),11日13-quien-20-oic酸1,20-lactone (2), labda-5 (10), 13 (E) -dien-15-ol(11),一个新的天然产物(2 E 6 E) 3, 7-dimethyl-9 - [(1 s, 6 r) 1、2,6-trimethylcyclohex-2-enyl] nona-2, 6-dien-1-ol(16)和13个已知化合物优秀的抗菌活动分数的孤立和阐明迷迭香属officinalis乙醇提取。结合文献报道，通过光谱分析确定了分离化合物的结构。其中单环二萜（16和17）为首次从迷迭香中发现。所有化合物对枯草芽孢杆菌、金黄色葡萄球菌、铜绿假单胞菌和镰刀菌的抑菌活性进行了测试，其中6个化合物对枯草芽孢杆菌有很强的抑菌活性，4个化合物对铜绿假单胞菌有很强的抑菌活性。

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来源期刊

Steroids 医学-内分泌学与代谢

CiteScore

5.10

自引率

3.70%

发文量

120

审稿时长

73 days

期刊介绍： STEROIDS is an international research journal devoted to studies on all chemical and biological aspects of steroidal moieties. The journal focuses on both experimental and theoretical studies on the biology, chemistry, biosynthesis, metabolism, molecular biology, physiology and pharmacology of steroids and other molecules that target or regulate steroid receptors. Manuscripts presenting clinical research related to steroids, steroid drug development, comparative endocrinology of steroid hormones, investigations on the mechanism of steroid action and steroid chemistry are all appropriate for submission for peer review. STEROIDS publishes both original research and timely reviews. For details concerning the preparation of manuscripts see Instructions to Authors, which is published in each issue of the journal.