Navigating the molecular landscape of Candida auris in a tertiary care setting in Eastern India

IF 1.4 4区医学 Q4 IMMUNOLOGY

Indian Journal of Medical Microbiology Pub Date : 2025-03-01 DOI:10.1016/j.ijmmb.2025.100814

Pritika Gahlot , Vinaykumar Hallur , Bijayini Behera , Prashanth Purushotham , Diptanu Paul , Jawahar Pillai , Swagata Tripathy , Anupam Dey , Krishna Mohan Gulla , Madhuchhanda Das , Shivaprakash M. Rudramurthy

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引用次数: 0

Abstract

Purpose

Candida auris was recently listed as a critical priority fungal pathogen by WHO due to its multidrug resistance and enhanced propensity for nosocomial transmission. This study investigated the molecular epidemiology and colonization patterns of C. auris in a tertiary care center in Eastern India.

Methods

A total of 201 patients from different intensive care units (ICUs) were enrolled, with colonization rates determined through enrichment followed by culture on chromogenic agar and molecular confirmation using Candida auris specific polymerase chain reaction (PCR) and antifungal susceptibility testing was done using microbroth dilution. For molecular characterization Fluorescent Amplified Fragment Polymorphism (FAFLP) was used.

Results

FAFLP revealed multiple clusters of strains, predominantly belonging to clade I, with notable isolates closely associated with clades III, IV, and V, previously unreported in India. Antifungal susceptibility testing found high resistance to amphotericin B (59.6 %) and low resistance to fluconazole compared to older studies (59.6 %), underscoring the need for further investigation. Sustained transmission of C. auris was observed despite infection control measures, emphasizing the ongoing challenges in infection control and the necessity for continuous surveillance.

Conclusion

This study contributes valuable insights into the epidemiology and genetic diversity of C. auris in Eastern India, highlighting the need for further investigations to understand transmission dynamics and clinical implications and underscores the importance of ongoing surveillance in combating this emerging pathogen.

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来源期刊

Indian Journal of Medical Microbiology IMMUNOLOGY-

CiteScore

2.20

自引率

0.00%

发文量

154

审稿时长

73 days

期刊介绍： Manuscripts of high standard in the form of original research, multicentric studies, meta analysis, are accepted. Current reports can be submitted as brief communications. Case reports must include review of current literature, clinical details, outcome and follow up. Letters to the editor must be a comment on or pertain to a manuscript already published in the IJMM or in relation to preliminary communication of a larger study. Review articles, Special Articles or Guest Editorials are accepted on invitation.