MXene-loaded multifunctional nanoparticles with on-demand controlled antimicrobial and antioxidant capacity for multi-modal treating bacterial prostatitis
Kailai Liu , Yanyao Gao , Yuchen Zhang , Yunhe Zheng , Jiangchuan He , Yu Huang , Xi Chen , Ruixiao Li , Qiang Fu , Bin Song , He Wang , Lei Wang , Geng Zhang , Ke Wang
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引用次数: 0
Abstract
Bacterial prostatitis represents a specific form of prostatitis, primarily resulting from bacterial infection and significantly impairing the life quality of patients. In this paper, we respond to the inability of conventional drugs to simultaneously address both bacterial infection and oxidative stress in the treatment of prostatitis by designing a multifunctional nanoparticle, called QM (Cu) NPs, with dual functionality. QM (Cu) NPs have the capacity to generate reactive oxygen radicals to eradicate bacteria under the influence of laser irradiation. Additionally, they are capable of rapidly scavenging the surplus free radicals, thereby restoring the intracellular redox homeostasis in the absence of laser illumination. A comprehensive characterization of QM (Cu) NPs was conducted, followed by an in-depth analysis of their effects on cells. The therapeutic efficacy of QM (Cu) NPs in multimodal treating bacterial prostatitis was then demonstrated. Furthermore, the outcomes of transcriptomic and molecular biology experiments indicated that QM (Cu) NPs markedly regulate the NF-κB p65 and Nrf2-Keap1 signaling pathways, thereby influencing inflammatory and oxidative stress processes. In conclusion, QM (Cu) NPs simultaneously addressed the dual challenges of antibacterial and antioxidant properties, thereby underscoring their potential clinical applications in the treatment of bacterial prostatitis.
期刊介绍:
Biomaterials is an international journal covering the science and clinical application of biomaterials. A biomaterial is now defined as a substance that has been engineered to take a form which, alone or as part of a complex system, is used to direct, by control of interactions with components of living systems, the course of any therapeutic or diagnostic procedure. It is the aim of the journal to provide a peer-reviewed forum for the publication of original papers and authoritative review and opinion papers dealing with the most important issues facing the use of biomaterials in clinical practice. The scope of the journal covers the wide range of physical, biological and chemical sciences that underpin the design of biomaterials and the clinical disciplines in which they are used. These sciences include polymer synthesis and characterization, drug and gene vector design, the biology of the host response, immunology and toxicology and self assembly at the nanoscale. Clinical applications include the therapies of medical technology and regenerative medicine in all clinical disciplines, and diagnostic systems that reply on innovative contrast and sensing agents. The journal is relevant to areas such as cancer diagnosis and therapy, implantable devices, drug delivery systems, gene vectors, bionanotechnology and tissue engineering.