Nitration of deactivated aromatic compounds using Lithium nitrate

IF 1.5 4区化学 Q3 CHEMISTRY, ORGANIC

Tetrahedron Letters Pub Date : 2025-03-03 DOI:10.1016/j.tetlet.2025.155515

Weihao Ma , J. Tyler McBride , Robert S. Phillips

引用次数: 0

Abstract

Nitroarenes are critically important in medicinal chemistry, material science, and the chemical industry. In this paper, we introduce a new strategy for the electrophilic nitration of deactivated aromatic compounds, utilizing lithium nitrate (LiNO₃) in the presence of sulfuric acid in trifluoroacetic acid. This method has demonstrated moderate to excellent yield. Mild reaction conditions and easy workup make the synthesis of nitro compounds both practical and commercially feasible.

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来源期刊

Tetrahedron Letters 化学-有机化学

CiteScore

3.50

自引率

5.60%

发文量

521

审稿时长

28 days

期刊介绍： Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.