Enantioselective Desymmetrization of Phosphinic Acids via Cu-Catalyzed O-Arylation

IF 11.3 1区化学 Q1 CHEMISTRY, PHYSICAL

ACS Catalysis Pub Date : 2025-03-06 DOI:10.1021/acscatal.5c00439

Ming Yan, Jia-wei Zou, Dong-mei Fang, Shi-qi Zhang, Xin Cui, Zhuo Tang, Guang-xun Li

引用次数: 0

Abstract

Enantioselective desymmetrization of phosphinic acid with two completely different carbon substituents on the P atom is an efficient way to obtain chiral P(V) compounds with high structural diversity. Herein, we reported a Cu-catalyzed asymmetric arylation of phosphinic acid, which turns the P-center to be a versatile electrophile for obtaining a series of chiral P(V) compounds, including phosphinates, phosphinamides, and tertiary phosphine oxides, in good yields and high enantioselectivities.

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来源期刊

ACS Catalysis CHEMISTRY, PHYSICAL-

CiteScore

20.80

自引率

6.20%

发文量

1253

审稿时长

1.5 months

期刊介绍： ACS Catalysis is an esteemed journal that publishes original research in the fields of heterogeneous catalysis, molecular catalysis, and biocatalysis. It offers broad coverage across diverse areas such as life sciences, organometallics and synthesis, photochemistry and electrochemistry, drug discovery and synthesis, materials science, environmental protection, polymer discovery and synthesis, and energy and fuels. The scope of the journal is to showcase innovative work in various aspects of catalysis. This includes new reactions and novel synthetic approaches utilizing known catalysts, the discovery or modification of new catalysts, elucidation of catalytic mechanisms through cutting-edge investigations, practical enhancements of existing processes, as well as conceptual advances in the field. Contributions to ACS Catalysis can encompass both experimental and theoretical research focused on catalytic molecules, macromolecules, and materials that exhibit catalytic turnover.