Evaluation of electrophysiological changes before and after pramipexole treatment in patients diagnosed with idiopathic restless legs syndrome.

IF 0.9 4区医学 Q4 CLINICAL NEUROLOGY

Ideggyogyaszati Szemle-Clinical Neuroscience Pub Date : 2025-01-30 DOI:10.18071/isz.78.0037

Tekesin Aysel, Erten Nilgun, Cimen Atalar Arife

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引用次数: 0

Abstract

Background and purpose: Restless legs syndrome (RLS) is a neurological disorder characterized by an irresistible urge to move the legs, frequently accompanied by unplea-sant sensations. In this study, we aimed to determine the changes in electrophysiologi-cal tests including F-wave responses and H-reflex parameters in patients with idiopathic RLS after pramipexole medication.

Methods: This prospective study was con-ducted with twenty newly diagnosed, idiopathic RLS patients. The electrophysiological parameters, specifically F-wave duration (FWD), the duration of related compound muscle action potential (CMAPD), and FWD/CMAPD ratio, the ratio of maximum H-reflex amplitude(H) to maximum M-response amplitude (M)(H/M) were recorded in patients with idiopathic RLS before and after pramipexole medication.

Results: The results revealed significant improvements in specific electrophysio-lo-gical parameters after pramipexole use. We observed a significant decrease in FWD, CMAPD, and FWD/CMAPD values after pra-mipexole treatment suggesting a reduction in motor neuron excitability. We also ob-ser-ved a significant decrease in H/M ratio after pramipexole medication indicating reduced spinal motor neuron excitability.

Conclusion: This study demonstrated significant improvement in specific electrophysiological parameters following pramipexole treatment in patients with idiopathic RLS. The findings provide better understanding of the effects of pramipexole on nerve function and may contribute to the development of a monitoring tool and lead to more targeted treatments and interventions for RLS, improving the overall management and care for patients' outcomes and quality of life with this debilitating condition.

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特发性不宁腿综合征患者普拉克索治疗前后电生理变化的评价。

背景和目的：不宁腿综合征（RLS）是一种神经系统疾病，其特征是无法抗拒的移动腿部的冲动，经常伴有不愉快的感觉。在本研究中，我们旨在确定特发性RLS患者在服用普拉克索后电生理测试的变化，包括f波反应和h反射参数。方法：对20例新诊断的特发性RLS患者进行前瞻性研究。记录特发性RLS患者服用普拉克索前后的电生理参数，特别是f波持续时间（FWD）、相关复合肌动作电位（CMAPD）持续时间、FWD/CMAPD比值、最大H反射幅度(H)与最大M反应幅度(M)之比（H/M）。结果：使用普拉克索后，特定电生理参数有显著改善。我们观察到普拉克索治疗后FWD、CMAPD和FWD/CMAPD值显著降低，表明运动神经元兴奋性降低。我们还观察到服用普拉克索后H/M比值显著降低，表明脊髓运动神经元兴奋性降低。结论：本研究表明，特发性RLS患者接受普拉克索治疗后，其特定电生理参数有显著改善。该研究结果有助于更好地了解普拉克索对神经功能的影响，并可能有助于开发一种监测工具，并导致对RLS的更有针对性的治疗和干预，改善对这种衰弱性疾病患者结果和生活质量的整体管理和护理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ideggyogyaszati Szemle-Clinical Neuroscience CLINICAL NEUROLOGY-NEUROSCIENCES

CiteScore

1.30

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： The aim of Clinical Neuroscience (Ideggyógyászati Szemle) is to provide a forum for the exchange of clinical and scientific information for a multidisciplinary community. The Clinical Neuroscience will be of primary interest to neurologists, neurosurgeons, psychiatrist and clinical specialized psycholigists, neuroradiologists and clinical neurophysiologists, but original works in basic or computer science, epidemiology, pharmacology, etc., relating to the clinical practice with involvement of the central nervous system are also welcome.