Pocket guide: biologics in upper and lower airways in adults.

IF 4.8 2区 医学 Q1 OTORHINOLARYNGOLOGY
Rhinology Pub Date : 2025-04-01 DOI:10.4193/Rhin24.510
W J Fokkens, V Backer, V J Lund, P J Barnes, M Bernal-Sprekelsen, L Bjermer, E de Corso, D M Conti, M E Cornet, Z Diamant, R Djukanovic, M Gaga, P Gevaert, J K Han, C Hopkins, G Joos, B N Landis, S Lau, S E Lee, J Mullol, A T Peters, G K Scadding, S Schneider, B Senior, I D Pavord, S Quirce, D Ryan, M E Wechsler, P W Hellings
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引用次数: 0

Abstract

The introduction of biologics for the treatment of severe upper and lower (type 2) airway inflammation has been a game changer in the management of these diseases. Biologics are injectable medications targeting different molecules relevant in (type 2) inflammation in patients with severe (type 2) airway diseases, like asthma, eosinophilic chronic obstructive pulmonary disease (COPD), chronic rhinosinusitis (CRS) and those who remain uncontrolled despite regular treatment. After the phase 3 trials, showing significant impact on symptoms, quality of life and interventions like surgery (for the upper airways) and exacerbations needing hospitalisation (for the lower airways), biologics are now used in daily practice in many parts of the world. This pocket guide is aimed at all specialists treating adult patients with severe airway disease.

袖珍指南:成人上下气道生物制剂。
引入生物制剂治疗严重的上、下(2型)气道炎症已经改变了这些疾病的管理。生物制剂是针对严重(2型)气道疾病患者(如哮喘、嗜酸性慢性阻塞性肺疾病(COPD)、慢性鼻窦炎(CRS)以及尽管常规治疗仍未控制的患者)中与(2型)炎症相关的不同分子的可注射药物(1-3)。在3期试验之后,生物制剂显示出对症状、生活质量和干预措施(如手术(上呼吸道)和需要住院治疗的恶化(下呼吸道))的显著影响,现在在世界许多地方的日常实践中使用生物制剂(4,5)。本口袋指南针对的是治疗患有严重气道疾病的成人患者的所有专家。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Rhinology
Rhinology 医学-耳鼻喉科学
CiteScore
15.80
自引率
9.70%
发文量
135
审稿时长
6-12 weeks
期刊介绍: Rhinology serves as the official Journal of the International Rhinologic Society and is recognized as one of the journals of the European Rhinologic Society. It offers a prominent platform for disseminating rhinologic research, reviews, position papers, task force reports, and guidelines to an international scientific audience. The journal also boasts the prestigious European Position Paper in Rhinosinusitis (EPOS), a highly influential publication first released in 2005 and subsequently updated in 2007, 2012, and most recently in 2020. Employing a double-blind peer review system, Rhinology welcomes original articles, review articles, and letters to the editor.
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