Extended-spectrum β-lactamase-producing Enterobacterales infections among infants following vertical colonization in a neonatal intensive care unit.

IF 2.4 3区医学 Q2 OBSTETRICS & GYNECOLOGY

Journal of Perinatology Pub Date : 2025-03-05 DOI:10.1038/s41372-025-02256-7

Mimori Abe, Yuto Otsubo, Tomoyuki Tame, Kaoru Okazaki, Yuho Horikoshi

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引用次数: 0

Abstract

Objective: Extended-spectrum β-lactamase-producing Enterobacterales (ESBL-E) has become prevalent among neonates. The present study aimed to describe the incidence of ESBL-E colonization among neonates admitted to a NICU and the incidence of subsequent ESBL-E infection among those with ESBL-E colonization.

Study design: Patients admitted to the NICU at Tokyo Metropolitan Children's Medical Center between April 2011 and March 2023 were enrolled. On admission, the subjects were routinely screened for ESBL-E using pharyngeal and rectal swabs, and those colonized with ESBL-E were assessed for the development of an invasive ESBL-E infection during their NICU stay.

Results: ESBL-E was isolated in 105 of the 8247 neonates (1.3%) admitted to the NICU. Among these patients, 12 (11.4%) experienced the development of an invasive ESBL-E infection.

Conclusion: Although ESBL-E colonization occurred in only 1.3% of the neonates admitted to the NICU, 11.4% of them experienced the development of an ESBL-E infection.

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来源期刊

Journal of Perinatology 医学-妇产科学

CiteScore

5.40

自引率

6.90%

发文量

284

审稿时长

3-8 weeks

期刊介绍： The Journal of Perinatology provides members of the perinatal/neonatal healthcare team with original information pertinent to improving maternal/fetal and neonatal care. We publish peer-reviewed clinical research articles, state-of-the art reviews, comments, quality improvement reports, and letters to the editor. Articles published in the Journal of Perinatology embrace the full scope of the specialty, including clinical, professional, political, administrative and educational aspects. The Journal also explores legal and ethical issues, neonatal technology and product development. The Journal’s audience includes all those that participate in perinatal/neonatal care, including, but not limited to neonatologists, perinatologists, perinatal epidemiologists, pediatricians and pediatric subspecialists, surgeons, neonatal and perinatal nurses, respiratory therapists, pharmacists, social workers, dieticians, speech and hearing experts, other allied health professionals, as well as subspecialists who participate in patient care including radiologists, laboratory medicine and pathologists.