Extended-spectrum β-lactamase-producing Enterobacterales infections among infants following vertical colonization in a neonatal intensive care unit.

IF 2.4 3区医学 Q2 OBSTETRICS & GYNECOLOGY

Journal of Perinatology Pub Date : 2025-03-05 DOI:10.1038/s41372-025-02256-7

Mimori Abe, Yuto Otsubo, Tomoyuki Tame, Kaoru Okazaki, Yuho Horikoshi

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引用次数: 0

Abstract

Objective: Extended-spectrum β-lactamase-producing Enterobacterales (ESBL-E) has become prevalent among neonates. The present study aimed to describe the incidence of ESBL-E colonization among neonates admitted to a NICU and the incidence of subsequent ESBL-E infection among those with ESBL-E colonization.

Study design: Patients admitted to the NICU at Tokyo Metropolitan Children's Medical Center between April 2011 and March 2023 were enrolled. On admission, the subjects were routinely screened for ESBL-E using pharyngeal and rectal swabs, and those colonized with ESBL-E were assessed for the development of an invasive ESBL-E infection during their NICU stay.

Results: ESBL-E was isolated in 105 of the 8247 neonates (1.3%) admitted to the NICU. Among these patients, 12 (11.4%) experienced the development of an invasive ESBL-E infection.

Conclusion: Although ESBL-E colonization occurred in only 1.3% of the neonates admitted to the NICU, 11.4% of them experienced the development of an ESBL-E infection.

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新生儿重症监护病房垂直定植后婴儿中产β-内酰胺酶肠杆菌的广谱感染

目的：广谱产β-内酰胺酶肠杆菌（ESBL-E）在新生儿中普遍存在。本研究旨在描述入住NICU的新生儿中ESBL-E定植的发生率以及ESBL-E定植的新生儿中随后ESBL-E感染的发生率。研究设计：纳入2011年4月至2023年3月期间在东京都儿童医疗中心NICU住院的患者。入院时，使用咽拭子和直肠拭子对受试者进行常规ESBL-E筛查，并评估那些有ESBL-E定植的患者在新生儿重症监护病房住院期间是否发生侵袭性ESBL-E感染。结果：8247例新生儿中有105例（1.3%）分离出ESBL-E。在这些患者中，12例（11.4%）发生了侵袭性ESBL-E感染。结论：虽然入住NICU的新生儿中仅有1.3%发生ESBL-E定植，但其中11.4%发生了ESBL-E感染。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Perinatology 医学-妇产科学

CiteScore

5.40

自引率

6.90%

发文量

284

审稿时长

3-8 weeks

期刊介绍： The Journal of Perinatology provides members of the perinatal/neonatal healthcare team with original information pertinent to improving maternal/fetal and neonatal care. We publish peer-reviewed clinical research articles, state-of-the art reviews, comments, quality improvement reports, and letters to the editor. Articles published in the Journal of Perinatology embrace the full scope of the specialty, including clinical, professional, political, administrative and educational aspects. The Journal also explores legal and ethical issues, neonatal technology and product development. The Journal’s audience includes all those that participate in perinatal/neonatal care, including, but not limited to neonatologists, perinatologists, perinatal epidemiologists, pediatricians and pediatric subspecialists, surgeons, neonatal and perinatal nurses, respiratory therapists, pharmacists, social workers, dieticians, speech and hearing experts, other allied health professionals, as well as subspecialists who participate in patient care including radiologists, laboratory medicine and pathologists.