{"title":"An unusual association: gastric xanthelasma presenting with iron deficiency anemia: a case report.","authors":"Yuksel Dogan, Adnan Mesut Dede, Arzu Erdoğan","doi":"10.1186/s13256-025-05133-1","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Gastric xanthelasma is a rare, benign lesion with uncertain clinical significance. Despite its asymptomatic nature, it may coexist with conditions like chronic gastritis and iron deficiency anemia.</p><p><strong>Case presentation: </strong>A 71-year-old Turkish male presented with iron deficiency anemia, chronic fatigue, and upper abdominal pain. Endoscopy revealed yellowish-white plaques (2-6 mm) on the antral mucosa, confirmed as gastric xanthelasma on histopathology. Concurrently, a rectal sessile polyp was excised during colonoscopy. The patient recovered following a 3-month course of oral iron supplementation and proton pump inhibitors. Follow-up endoscopy showed resolution of gastric lesions.</p><p><strong>Conclusion: </strong>This report underscores the diagnostic importance of endoscopy and biopsy in patients with unexplained anemia and highlights the potential association between gastric xanthelasma and ron deficiency anemia, warranting further research.</p>","PeriodicalId":16236,"journal":{"name":"Journal of Medical Case Reports","volume":"19 1","pages":"98"},"PeriodicalIF":0.9000,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11881478/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Medical Case Reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1186/s13256-025-05133-1","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
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Abstract
Background: Gastric xanthelasma is a rare, benign lesion with uncertain clinical significance. Despite its asymptomatic nature, it may coexist with conditions like chronic gastritis and iron deficiency anemia.
Case presentation: A 71-year-old Turkish male presented with iron deficiency anemia, chronic fatigue, and upper abdominal pain. Endoscopy revealed yellowish-white plaques (2-6 mm) on the antral mucosa, confirmed as gastric xanthelasma on histopathology. Concurrently, a rectal sessile polyp was excised during colonoscopy. The patient recovered following a 3-month course of oral iron supplementation and proton pump inhibitors. Follow-up endoscopy showed resolution of gastric lesions.
Conclusion: This report underscores the diagnostic importance of endoscopy and biopsy in patients with unexplained anemia and highlights the potential association between gastric xanthelasma and ron deficiency anemia, warranting further research.
期刊介绍：
JMCR is an open access, peer-reviewed online journal that will consider any original case report that expands the field of general medical knowledge. Reports should show one of the following: 1. Unreported or unusual side effects or adverse interactions involving medications 2. Unexpected or unusual presentations of a disease 3. New associations or variations in disease processes 4. Presentations, diagnoses and/or management of new and emerging diseases 5. An unexpected association between diseases or symptoms 6. An unexpected event in the course of observing or treating a patient 7. Findings that shed new light on the possible pathogenesis of a disease or an adverse effect
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