Health conditions in adults with atrial fibrillation compared with the general population: a population-based cross-sectional analysis.

IF 5.1 2区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Heart Pub Date : 2025-06-13 DOI:10.1136/heartjnl-2024-324618

Thomas J Downes, Bruce Guthrie, David Moreno-Martos, Daniel R Morales

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引用次数: 0

Abstract

Background: Atrial fibrillation (AF) prevalence is rising due to population ageing and comorbidity is an increasing problem. The aim of this study was to examine the prevalence and association of coexisting health conditions among adults with AF in the general population.

Methods: Cross-sectional analysis of Clinical Practice Research Datalink (CPRD) primary care electronic medical records in England linked to hospital admissions as of 30 November 2015. CPRD is broadly representative of the UK general population in terms of age, sex and ethnicity. We estimated prevalence and used logistic regression examining risk factors of age, sex and socioeconomic status (SES) to compare prevalence of 252 physical and mental health conditions and 23 higher level health condition groups in adults with AF compared with adults without AF.

Results: 34 338 adults with AF (57% male; 83% ≥65 years) and 907 739 without AF (49% male; 23% ≥65 years) were identified. Adjusted for age and sex, adults with AF were significantly more likely to have 20/23 (87%) health condition groups than adults without AF. The most prevalent health condition groups in adults with AF were cardiovascular (prevalence of 89% in adults with AF vs 26% in adults without AF, adjusted OR (aOR) 5.82, 95% CI 5.60 to 6.05), gastrointestinal (62% vs 37%, aOR 1.34, 95% CI 1.31 to 1.38) and orthopaedic (58% vs 24%, aOR 1.32, 95% CI 1.29 to 1.35). 151/252 individual conditions were significantly more common in adults with AF including cardiovascular conditions such as cardiomyopathy (4.5% vs 0.3%, aOR 9.58, 95% CI 8.88 to 10.35) and heart failure (18% vs 0.7%, aOR 9.07, 95% CI 8.70 to 9.46), and non-cardiovascular conditions such as pleural effusion (16% vs 1.8%, aOR 3.55, 95% CI 3.42 to 3.67) and oesophageal malignancy (0.3% vs 0.0%, aOR 2.14, 95% CI 1.69 to 2.70). Associations were similar after SES adjustment.

Conclusions: While cardiovascular conditions are highly prevalent and strongly associated with AF, a wide spectrum of non-cardiovascular conditions were also strongly associated, requiring a greater understanding of managing comorbid conditions with management principles contradictory to AF.

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成人房颤患者的健康状况与普通人群的比较：基于人群的横断面分析

背景：由于人口老龄化，房颤（AF）的患病率正在上升，合并症是一个日益严重的问题。本研究的目的是检查普通人群中房颤成人共存健康状况的患病率和相关性。方法：对截至2015年11月30日的英国临床实践研究数据链（CPRD）初级保健电子病历进行横断面分析。CPRD在年龄、性别和种族方面广泛代表了英国普通人口。我们估计了房颤的患病率，并使用logistic回归检查了年龄、性别和社会经济地位（SES）的危险因素，比较了房颤成人与非房颤成人在252种身体和精神健康状况和23种更高水平健康状况组中的患病率。≥65岁的83%)，无房颤的907739例(男性49%；23%≥65岁)。调整年龄和性别,成年人与房颤明显更可能比成人有20/23(87%)的健康状况组没有房颤。最普遍的成人AF是心血管健康状况团体(患病率89%的成年人AF vs 26%成年人没有房颤,调整或(aOR)为5.82,95%可信区间5.60到6.05),胃肠道(62% vs 37%,优势比1.34,95%可信区间1.31到1.38)和骨科(58% vs 24%,优势比1.32,95%可信区间1.29到1.35)。151/252个体疾病在成人房颤患者中更为常见，包括心血管疾病，如心肌病（4.5%对0.3%,aOR 9.58, 95% CI 8.88至10.35）和心力衰竭（18%对0.7%,aOR 9.07, 95% CI 8.70至9.46），以及非心血管疾病，如胸腔积液（16%对1.8%,aOR 3.55, 95% CI 3.42至3.67）和食管恶性肿瘤（0.3%对0.0%,aOR 2.14, 95% CI 1.69至2.70）。经SES调整后，相关性相似。结论：虽然心血管疾病与房颤高度普遍且密切相关，但广泛的非心血管疾病也与房颤密切相关，因此需要更深入地了解与房颤相矛盾的管理原则的合并症的管理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Heart 医学-心血管系统

CiteScore

10.30

自引率

5.30%

发文量

320

审稿时长

3-6 weeks

期刊介绍： Heart is an international peer reviewed journal that keeps cardiologists up to date with important research advances in cardiovascular disease. New scientific developments are highlighted in editorials and put in context with concise review articles. There is one free Editor’s Choice article in each issue, with open access options available to authors for all articles. Education in Heart articles provide a comprehensive, continuously updated, cardiology curriculum.