Novel impact of metal ion-induced cell death on diabetic cardiomyopathy pathogenesis and therapy

IF 8.1 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Apoptosis Pub Date : 2025-03-05 DOI:10.1007/s10495-025-02090-4

Jingjing Jiang, Shengnan Hu, Kaibo Hu, Leyang Xiao, Jitao Lin, Yixuan Chen, Deju Zhang, Yangliu Ou, Jing Zhang, Linhui Yuan, Wenting Wang, Peng Yu

{"title":"Novel impact of metal ion-induced cell death on diabetic cardiomyopathy pathogenesis and therapy","authors":"Jingjing Jiang, Shengnan Hu, Kaibo Hu, Leyang Xiao, Jitao Lin, Yixuan Chen, Deju Zhang, Yangliu Ou, Jing Zhang, Linhui Yuan, Wenting Wang, Peng Yu","doi":"10.1007/s10495-025-02090-4","DOIUrl":null,"url":null,"abstract":"<div><p>Diabetes mellitus is a common chronic metabolic disease, with its prevalence escalating annually. Diabetic cardiomyopathy is a leading cause of mortality among diabetic patients, characterized by intricate metabolic disturbances and myocardial cell demise. Various forms of cellular death pathways including apoptosis, pyroptosis, autophagic cell death, necroptosis, ferroptosis, and entosis have been identified in diabetic cardiomyopathy. Inhibiting myocardial cell death pathways has shown promise in mitigating diabetic cardiomyopathy progression. However, there are still gaps in understanding the role of metal ions in diabetic cardiomyopathy pathogenesis. Recent research endeavors have found that iron, copper, zinc, calcium, manganese and other metal elements related to cell death play an intricate and critical role in the pathogenesis and progression of diabetic cardiomyopathy. Notably, many animal studies have shown that the development and progression of diabetic cardiomyopathy can be alleviated by inhibiting the cell death process induced by these metal ions. Therefore, we review the molecular mechanisms underlying the death of various metal ions and the potential pathophysiological roles they play in diabetic cardiomyopathy. In addition, the value of these metal ions in the treatment of diabetic cardiomyopathy is also described.</p><h3>Graphic abstract</h3>\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":8062,"journal":{"name":"Apoptosis","volume":"30 5-6","pages":"1152 - 1181"},"PeriodicalIF":8.1000,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Apoptosis","FirstCategoryId":"99","ListUrlMain":"https://link.springer.com/article/10.1007/s10495-025-02090-4","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Diabetes mellitus is a common chronic metabolic disease, with its prevalence escalating annually. Diabetic cardiomyopathy is a leading cause of mortality among diabetic patients, characterized by intricate metabolic disturbances and myocardial cell demise. Various forms of cellular death pathways including apoptosis, pyroptosis, autophagic cell death, necroptosis, ferroptosis, and entosis have been identified in diabetic cardiomyopathy. Inhibiting myocardial cell death pathways has shown promise in mitigating diabetic cardiomyopathy progression. However, there are still gaps in understanding the role of metal ions in diabetic cardiomyopathy pathogenesis. Recent research endeavors have found that iron, copper, zinc, calcium, manganese and other metal elements related to cell death play an intricate and critical role in the pathogenesis and progression of diabetic cardiomyopathy. Notably, many animal studies have shown that the development and progression of diabetic cardiomyopathy can be alleviated by inhibiting the cell death process induced by these metal ions. Therefore, we review the molecular mechanisms underlying the death of various metal ions and the potential pathophysiological roles they play in diabetic cardiomyopathy. In addition, the value of these metal ions in the treatment of diabetic cardiomyopathy is also described.

Graphic abstract

查看原文本刊更多论文

金属离子诱导细胞死亡对糖尿病心肌病发病机制和治疗的新影响。

糖尿病是一种常见的慢性代谢性疾病，其患病率逐年上升。糖尿病性心肌病是糖尿病患者死亡的主要原因，其特点是复杂的代谢紊乱和心肌细胞死亡。各种形式的细胞死亡途径，包括凋亡、焦亡、自噬细胞死亡、坏死坏死、铁亡和内源性死亡，已经在糖尿病心肌病中被发现。抑制心肌细胞死亡途径在减轻糖尿病心肌病进展方面显示出希望。然而，金属离子在糖尿病性心肌病发病机制中的作用仍存在空白。近年来的研究发现，铁、铜、锌、钙、锰等与细胞死亡相关的金属元素在糖尿病心肌病的发病和发展中起着复杂而关键的作用。值得注意的是，许多动物研究表明，通过抑制这些金属离子诱导的细胞死亡过程，可以减轻糖尿病性心肌病的发生和进展。因此，我们对各种金属离子死亡的分子机制及其在糖尿病心肌病中的潜在病理生理作用进行了综述。此外，还介绍了这些金属离子在糖尿病性心肌病治疗中的价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Apoptosis 生物-生化与分子生物学

CiteScore

9.10

自引率

4.20%

发文量

审稿时长

1 months

期刊介绍： Apoptosis, a monthly international peer-reviewed journal, focuses on the rapid publication of innovative investigations into programmed cell death. The journal aims to stimulate research on the mechanisms and role of apoptosis in various human diseases, such as cancer, autoimmune disease, viral infection, AIDS, cardiovascular disease, neurodegenerative disorders, osteoporosis, and aging. The Editor-In-Chief acknowledges the importance of advancing clinical therapies for apoptosis-related diseases. Apoptosis considers Original Articles, Reviews, Short Communications, Letters to the Editor, and Book Reviews for publication.