Influence of Carcinoma and Sarcoma on Neutrophil Gelatinase-Associated Lipocalin and Symmetric Dimethylarginine Concentrations in Dogs

IF 2.1 2区农林科学 Q1 VETERINARY SCIENCES

Journal of Veterinary Internal Medicine Pub Date : 2025-03-05 DOI:10.1111/jvim.70015

Anouska Rixon, Evelyne Meyer, Sylvie Daminet, Amelia Goddard, Thirawut Kongtasai, Paolo Pazzi

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Abstract

Background

It is unknown if tumors or concomitant renal disease influence neutrophil gelatinase–associated lipocalin (NGAL) and symmetric dimethylarginine (SDMA) concentrations in tumor-bearing dogs.

Objectives

Determine the effect of tumor presence, tumor type, and metastasis on concentrations of serum NGAL (sNGAL), SDMA, urinary NGAL (uNGAL), and uNGAL-to-creatinine ratio (uNGAL/Cr) in dogs with carcinoma or sarcoma without clinically relevant renal disease.

Animals

Twenty-one dogs with carcinoma, 18 with sarcoma, and 20 healthy age-controlled dogs.

Methods

Concentrations of sNGAL, SDMA, and uNGAL, and uNGAL/Cr ratio were measured from banked samples collected during a previous prospective study. Patient clinicopathological and histopathology records were reviewed, and those with renal azotemia or moderate to severe histopathological renal abnormalities were classified as having clinically relevant renal disease. Biomarker concentrations were compared between tumor-bearing dogs without clinically relevant renal disease and healthy age-controlled dogs. Additionally, comparisons were made between dogs with carcinoma and sarcoma, as well as between dogs with and without metastasis. Correlations between uNGAL and sNGAL concentrations, along with acute phase protein (APP) concentrations, were also analyzed.

Results

Tumor-bearing dogs without clinically relevant renal disease had increased uNGAL/Cr (p < 0.001), but not sNGAL, compared with healthy controls. Although median SDMA concentrations did not significantly differ between groups, increased concentrations were found in 32% of dogs with carcinoma and 20% of dogs with sarcoma. No differences were found between dogs with carcinoma and those with sarcoma, or between dogs with metastasis and those without. Urinary and serum NGAL concentrations were moderately correlated, while weak to no correlations were observed with APPs.

Conclusion

Carcinomas and sarcomas, but not metastasis, influence uNGAL/Cr and SDMA concentrations in dogs.

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癌症和肉瘤对犬中性粒细胞明胶酶相关脂钙蛋白和对称二甲基精氨酸浓度的影响

目前尚不清楚肿瘤或伴发肾脏疾病是否会影响荷瘤犬中性粒细胞明胶酶相关脂钙蛋白（NGAL）和对称二甲基精氨酸（SDMA）浓度。目的探讨肿瘤存在、肿瘤类型和转移对无临床相关性肾脏疾病的癌或肉瘤犬血清NGAL （sNGAL）、SDMA、尿NGAL （uNGAL）和uNGAL/肌酐比值（uNGAL/Cr）的影响。21只患有癌症的狗，18只患有肉瘤的狗，20只健康的年龄控制的狗。方法从前期前瞻性研究中收集的样本中测定sNGAL、SDMA和uNGAL的浓度以及uNGAL/Cr比值。回顾患者的临床病理和组织病理记录，将肾氮血症或中度至重度肾组织病理异常归类为临床相关肾脏疾病。比较无临床相关肾脏疾病的荷瘤犬和健康年龄控制犬的生物标志物浓度。此外，还比较了患癌和肉瘤的狗，以及有和没有转移的狗。还分析了uNGAL和sNGAL浓度以及急性期蛋白（APP）浓度之间的相关性。结果与健康对照相比，无临床相关肾脏疾病的携带肿瘤的狗uNGAL/Cr升高（p < 0.001），但sNGAL没有升高。虽然SDMA的中位浓度在两组之间没有显著差异，但在32%的癌犬和20%的肉瘤犬中发现浓度升高。在患癌的狗和患肉瘤的狗之间，或者在有转移的狗和没有转移的狗之间，没有发现差异。尿和血清NGAL浓度与app存在中度相关性，而与app的相关性较弱或无相关性。结论影响犬uNGAL/Cr和SDMA浓度的因素是肿瘤和肉瘤，而不是转移。

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来源期刊

Journal of Veterinary Internal Medicine 农林科学-兽医学

CiteScore

4.50

自引率

11.50%

发文量

243

审稿时长

22 weeks

期刊介绍： The mission of the Journal of Veterinary Internal Medicine is to advance veterinary medical knowledge and improve the lives of animals by publication of authoritative scientific articles of animal diseases.