Insulin-Loaded Graphene Oxide Microparticles: Synthesis, Characterization, Insulin Delivery, and Physical Interactions Analysis

IF 1.8 3区 化学 Q3 CHEMISTRY, INORGANIC & NUCLEAR
W. B. Huang, X. Y. Huang, R. Mu, T. Pei, C. P. Guo, X. Q. Bai
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引用次数: 0

Abstract

The graphene oxide (GO) microparticles were synthesized through ultrasonication for insulin delivery. The prepared GO microparticles and insulin-loaded GO/insulin composite were characterized by various techniques including ATR-FTIR (attenuated total reflection flourier transformed infrared spectroscopy), scanning electron microcopy (SEM), thermogravimetric analyzer (TG), zeta potential and dynamic lights scattering (DLS) measurements. The particle size analysis showed that the GO particle was well distributed, and the size was about 4 μm with surface charge of –27.5 mV in MES solution (pH 4.7). SEM images showed that insulin successfully attached on surface of GO particles. The GO particles exhibited excellent insulin loading efficiency in lower pH solution (2.5, 4.7). The release study showed that insulin was released from GO/insulin composite in higher pH solution (7.4). This study provides valuable information for development of insulin carriers based on GO.

Abstract Image

通过超声合成了用于胰岛素递送的氧化石墨烯(GO)微粒。通过衰减全反射傅立叶变换红外光谱(ATR-FTIR)、扫描电子显微镜(SEM)、热重分析仪(TG)、ZETA电位和动态光散射(DLS)测量等多种技术对制备的GO微粒和胰岛素负载GO/胰岛素复合材料进行了表征。粒度分析表明,GO 颗粒分布均匀,在 MES 溶液(pH 4.7)中的粒度约为 4 μm,表面电荷为 -27.5 mV。扫描电镜图像显示,胰岛素成功附着在 GO 粒子表面。在 pH 值较低的溶液(2.5、4.7)中,GO 颗粒表现出优异的胰岛素负载效率。释放研究表明,在较高的 pH 溶液(7.4)中,胰岛素从 GO/胰岛素复合材料中释放出来。这项研究为开发基于 GO 的胰岛素载体提供了宝贵的信息。
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来源期刊
Russian Journal of Inorganic Chemistry
Russian Journal of Inorganic Chemistry 化学-无机化学与核化学
CiteScore
3.10
自引率
38.10%
发文量
237
审稿时长
3 months
期刊介绍: Russian Journal of Inorganic Chemistry is a monthly periodical that covers the following topics of research: the synthesis and properties of inorganic compounds, coordination compounds, physicochemical analysis of inorganic systems, theoretical inorganic chemistry, physical methods of investigation, chemistry of solutions, inorganic materials, and nanomaterials.
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