Cu–Zn@HA bimetallic nanozymes: a novel approach for ROS clearance and macrophage polarization in colitis therapy

IF 23.2 2区 材料科学 Q1 MATERIALS SCIENCE, COMPOSITES
Lin Cheng, Yun-kai Dai, Ningyi Zhang, Xiaotong Ye, Yuan Liao, Chun-hua Fan, Wen-ying Zhu, Shu-ling Xu, Liang Guo, Toujun Zou, Dongling Dai, Yu-jin Wu, Dan Liu
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引用次数: 0

Abstract

Inflammatory bowel disease (IBD) presents significant clinical challenges due to its multifaceted pathogenesis and the limited efficacy of existing therapies. This study investigates the therapeutic potential of Cu–Zn@HA bimetallic nanozymes for the treatment of colitis. Through in vivo experiments, we demonstrated that these nanozymes exhibit sustained retention in the colon, facilitating effective modulation of gut microbiota composition and diversity. Notably, Cu–Zn@HA nanozymes significantly enhanced α-diversity and induced distinct alterations in microbial community structure across treatment groups. While no marked differences were observed in the Firmicutes/Bacteroidetes ratio, our biomarker analyses indicated critical shifts in bacterial populations associated with gut health and inflammatory responses. Additionally, Cu–Zn@HA nanozymes effectively scavenged reactive oxygen species (ROS) and promoted macrophage polarization, contributing to an anti-inflammatory microenvironment. Importantly, our studies confirmed the excellent safety profile of these nanozymes. Collectively, these findings underscore the promising role of Cu–Zn@HA bimetallic nanozymes as a novel therapeutic strategy for IBD, paving the way for future investigations into their clinical efficacy and safety.

Cu - Zn@HA双金属纳米酶:结肠炎治疗中ROS清除和巨噬细胞极化的新方法
炎症性肠病(IBD)由于其多方面的发病机制和现有治疗方法的有效性有限,提出了重大的临床挑战。本研究探讨了Cu - Zn@HA双金属纳米酶治疗结肠炎的治疗潜力。通过体内实验,我们证明了这些纳米酶在结肠中表现出持续的保留,促进了肠道微生物群组成和多样性的有效调节。值得注意的是,Cu - Zn@HA纳米酶显著提高了α-多样性,并诱导了不同处理组微生物群落结构的明显变化。虽然厚壁菌门/拟杆菌门比例没有明显差异,但我们的生物标志物分析表明,与肠道健康和炎症反应相关的细菌种群发生了关键变化。此外,Cu - Zn@HA纳米酶有效清除活性氧(ROS),促进巨噬细胞极化,有助于抗炎微环境。重要的是,我们的研究证实了这些纳米酶的良好安全性。总的来说,这些发现强调了Cu - Zn@HA双金属纳米酶作为一种新的IBD治疗策略的有希望的作用,为未来研究其临床疗效和安全性铺平了道路。
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来源期刊
CiteScore
26.00
自引率
21.40%
发文量
185
期刊介绍: Advanced Composites and Hybrid Materials is a leading international journal that promotes interdisciplinary collaboration among materials scientists, engineers, chemists, biologists, and physicists working on composites, including nanocomposites. Our aim is to facilitate rapid scientific communication in this field. The journal publishes high-quality research on various aspects of composite materials, including materials design, surface and interface science/engineering, manufacturing, structure control, property design, device fabrication, and other applications. We also welcome simulation and modeling studies that are relevant to composites. Additionally, papers focusing on the relationship between fillers and the matrix are of particular interest. Our scope includes polymer, metal, and ceramic matrices, with a special emphasis on reviews and meta-analyses related to materials selection. We cover a wide range of topics, including transport properties, strategies for controlling interfaces and composition distribution, bottom-up assembly of nanocomposites, highly porous and high-density composites, electronic structure design, materials synergisms, and thermoelectric materials. Advanced Composites and Hybrid Materials follows a rigorous single-blind peer-review process to ensure the quality and integrity of the published work.
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