Leonarda Vugrin, Alen Bjelopetrović and Ivan Halasz
{"title":"Aza-Michael addition by ball milling†","authors":"Leonarda Vugrin, Alen Bjelopetrović and Ivan Halasz","doi":"10.1039/D4MR00133H","DOIUrl":null,"url":null,"abstract":"<p >Here, accompanied by <em>in situ</em> Raman monitoring, we adapt the aza-Michael addition for the formation of the C–N bond under mechanochemical conditions, enabling solvent- and catalyst-free synthesis and facile preparation of compounds that are challenging to obtain in solution.</p>","PeriodicalId":101140,"journal":{"name":"RSC Mechanochemistry","volume":" 2","pages":" 184-187"},"PeriodicalIF":0.0000,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/mr/d4mr00133h?page=search","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"RSC Mechanochemistry","FirstCategoryId":"1085","ListUrlMain":"https://pubs.rsc.org/en/content/articlelanding/2025/mr/d4mr00133h","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Here, accompanied by in situ Raman monitoring, we adapt the aza-Michael addition for the formation of the C–N bond under mechanochemical conditions, enabling solvent- and catalyst-free synthesis and facile preparation of compounds that are challenging to obtain in solution.