Aza-Michael addition by ball milling†

Leonarda Vugrin, Alen Bjelopetrović and Ivan Halasz
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Abstract

Here, accompanied by in situ Raman monitoring, we adapt the aza-Michael addition for the formation of the C–N bond under mechanochemical conditions, enabling solvent- and catalyst-free synthesis and facile preparation of compounds that are challenging to obtain in solution.

Abstract Image

Aza-Michael球磨加法†
在现场拉曼监测的同时,我们在机械化学条件下调整了aza-Michael加成以形成C-N键,从而实现了无溶剂和无催化剂的合成,并且易于制备在溶液中难以获得的化合物。
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