Synthesis of benzimidazo[1,2-c]quinazolin-6(5H)-one derivatives via copper-mediated C–H isocyanatation of 2-arylbenzimidazoles

IF 2.1 3区化学 Q2 CHEMISTRY, ORGANIC

Tetrahedron Pub Date : 2025-03-03 DOI:10.1016/j.tet.2025.134569

Ali Nasirpour, Zarrin Ghasemi

引用次数: 0

Abstract

An efficient protocol is disclosed for the synthesis of benzimidazo[1,2-c]quinazolin-6(5H)-ones utilizing an atom-economical C–H functionalization method. Copper-mediated isocyanatation of the aryl ring of the prepared 2-arylbenzimidazole derivatives, followed with intramolecular cyclization reaction resulted in the desired products. We diversified and purified the products without chromatography.

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通过铜介导的 2-芳基苯并咪唑 C-H 异氰酸化合成苯并咪唑并[1,2-c]喹唑啉-6(5H)-酮衍生物

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来源期刊

Tetrahedron 化学-有机化学

CiteScore

3.90

自引率

4.80%

发文量

439

审稿时长

34 days

期刊介绍： Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry. Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters. Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.