Otorhinolaryngological manifestations of autoinflammatory diseases. Systematic review

IF 0.9 Q3 OTORHINOLARYNGOLOGY
María Victoria Mallo-Miranda , Carmelo Morales-Angulo
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引用次数: 0

Abstract

Objectives

To detail the main otorhinolaryngological manifestations of autoinflammatory diseases, aiming to contribute to early diagnosis and treatment.

Data sources

Searches were conducted in PubMed, LILACS, Cochrane Library.

Review methods

A systematic review of the medical literature on autoinflammatory diseases was conducted to identify characteristic head and neck manifestations, using PRISMA criteria. Observational studies or systematic reviews with a minimum of 10 cases per disease were included. Qualitative synthesis and a risk assessment were carried out.

Results

Our review included 29 articles that met the inclusion criteria, with 10 to 486 patients per study. Autoinflammatory diseases with characteristic head and neck manifestations included VEXAS syndrome (auricular, nasal, or laryngotracheal chondritis), NPRL3-AID (hearing loss), NPRL12-AID (cervical lymphadenopathies, hearing loss and oral ulcers), HIDSs syndrome (painful cervical nodes and oral ulcers), haploinsufficiency A20 (oral ulcers), TRAPS (pharyngitis, aphthous stomatitis, periorbital edema, and cervical lymphadenopathies), Behcet’s disease (oral and pharyngeal ulcers), PFAPA syndrome (recurrent tonsillitis, oral ulcers, and painful cervical adenopathies), Kawasaki disease (cervical nodes, pharyngitis and changes in oral mucosa) and undefined periodic fever (pharyngitis, oral ulcers, and painful cervical nodes).

Conclusion

Given their complex diagnosis and unique head and neck manifestations, otolaryngologists must be well-versed in these diseases for early detection and treatment. ENT specialists should consider the possibility of an autoinflammatory disease when encountering symptoms such as auricular, nasal, or laryngeal chondritis, recurrent oral ulcers, painful inflammatory lymphadenopathies, periorbital edema, recurrent pharyngitis, or hearing loss within the context of compatible systemic conditions.
自身炎症性疾病的耳鼻喉科表现。系统综述
目的探讨自身炎症性疾病的主要耳鼻喉科表现,为早期诊断和治疗提供依据。数据来源检索PubMed, LILACS, Cochrane Library。回顾方法系统回顾自身炎症性疾病的医学文献,采用PRISMA标准确定特征性头颈部表现。每种疾病至少纳入10例的观察性研究或系统评价。进行了定性综合和风险评估。结果我们的综述纳入了29篇符合纳入标准的文章,每项研究纳入10至486例患者。以头颈部为特征性表现的自身炎症性疾病包括:VEXAS综合征(耳部、鼻部或喉气管软骨炎)、NPRL3-AID(听力损失)、NPRL12-AID(颈部淋巴结病、听力损失和口腔溃疡)、hids综合征(颈部淋巴结痛和口腔溃疡)、单倍功能不全A20(口腔溃疡)、TRAPS(咽炎、口腔炎、眼周水肿和颈部淋巴结病)、白塞病(口腔和咽部溃疡)、PFAPA综合征(复发性扁桃体炎、口腔溃疡和疼痛性宫颈腺病)、川崎病(宫颈淋巴结、咽炎和口腔黏膜改变)和不明周期性发热(咽炎、口腔溃疡和宫颈淋巴结疼痛)。结论耳鼻喉科医师因其复杂的诊断和独特的头颈部表现,必须对其有所了解,以便及早发现和治疗。耳鼻喉专科医生在遇到耳部、鼻部或喉部软骨炎、复发性口腔溃疡、疼痛性炎症性淋巴结病、眶周水肿、复发性咽炎或听力损失等症状时,应考虑自身炎症性疾病的可能性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
1.40
自引率
20.00%
发文量
44
审稿时长
44 days
期刊介绍: Es la revista más importante en español dedicada a la especialidad. Ofrece progresos científicos y técnicos tanto a nivel de originales como de casos clínicos. Además, es la Publicación Oficial de la Sociedad Española de Otorrinolaringología y Patología Cérvico-Facial y está presente en los más prestigiosos índices de referencia.
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