The effect of interleukin-33 expression on prognosis in patients with nasopharyngeal carcinoma

IF 0.9 Q3 OTORHINOLARYNGOLOGY
İbrahim Arslan , Hatice Yılmazçoban , Hülya Eyigör , Canan Sadullahoğlu , Derya Salim Kıvrak , Gözde Akgün , Ömer Tarık Selçuk
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引用次数: 0

Abstract

Introduction

Interleukin-33 (IL-33) is a newly defined inflammatory cytokine that is a member of the interleukin-1 (IL-1) gene family. This cytokine is expressed in structural cells, such as the vascular endothelium, bronchial epithelial cells, keratinocytes, epithelial cells of the stomach, and fibroblastic reticular cells of lymphoid tissues. Several studies suggest that IL-33 plays a role in head-and-neck cancer. The aim of this study was to retrospectively examine IL-33 expression in nasopharyngeal carcinoma (NPC) and to evaluate its relationship between clinicopathological characteristics and prognosis.

Methods

In this monocentric, retrospective analysis, the data of 43 cases diagnosed with primary NPC and 20 cases with normal nasopharyngeal tissue (diagnosed between 2014 and 2020) were evaluated regarding the relationship between the immunohistochemically analyzed IL-33 expression status and corresponding clinicopathological parameters.

Results

The mean age was 56.9 years. The majority (67.4%) of the patients had an early tumor stage (T1–T2). IL-33 expression was positive in 56% of the cases. The five-year overall survival rate was 77% for all patients, 90% for the patients with positive IL-33 expression, and 55% for those without IL-33 expression (p = 0.008, univariate analysis). In multivariate analysis, IL-33 expression was shown to be the only independent prognostic marker for nasopharyngeal carcinoma (p = 0.014).

Conclusion

This retrospective study showed that IL-33 expression could be considered an independent factor affecting positively prognosis in NPC.
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来源期刊
CiteScore
1.40
自引率
20.00%
发文量
44
审稿时长
44 days
期刊介绍: Es la revista más importante en español dedicada a la especialidad. Ofrece progresos científicos y técnicos tanto a nivel de originales como de casos clínicos. Además, es la Publicación Oficial de la Sociedad Española de Otorrinolaringología y Patología Cérvico-Facial y está presente en los más prestigiosos índices de referencia.
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