Mean Arteriolar Diameter Measured from Wide-Field Swept-Source OCT Angiography: A Highly Sensitive Indicator for Mean Arterial Pressure

IF 3.2 Q1 OPHTHALMOLOGY

Ophthalmology science Pub Date : 2024-12-17 DOI:10.1016/j.xops.2024.100679

Yuchen Li , Yuyao Qu , Hanze Zhang , Yue Bian , Langxuan Yuan , Jingbo Hu , Shengrui Xu , Xiayu Xu PhD , Jianqin Lei MD

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Abstract

Purpose

To investigate the metrics of retinal arterioles and venules based on the en face images of the superficial retina using wide-field swept-source OCT angiography (SSOCTA) and assess their relationships with specific systemic parameters in a normal sample.

Design

Cross-sectional study.

Participants

Normal volunteers with no history of hypertension, diabetes, or significant eye diseases were recruited at the outpatient clinic of the First Affiliated Hospital of Xi’an Jiaotong University. Eligible eyes had a corrected visual acuity of 20/25 or better and an intraocular pressure (IOP) not exceeding 21 mmHg.

Methods

The SSOCTA scans of 24 × 20 mm in size were acquired from both eyes of each participant, along with measurements of axial length (AL), IOP, real-time mean arterial pressure (MAP), and body mass index (BMI). Retinal arterioles and venules were manually segmented and distinguished from the disc margin to their capillary junctions in the superficial retinal layer. Image processing and calculations were performed using ImageJ.

Main Outcome Measurements

The averaged caliber and fractal dimension of arteries and veins, as well as the arteriovenous ratio, were calculated from binarized vascular images. Generalized linear mixed models were used to test correlations between systemic parameters and these metrics.

Results

A total of 54 eyes from 44 participants were included after screening. Univariate analysis revealed a significant negative impact of MAP on averaged caliber of retinal artery (B = −0.003, P = 0.004) and averaged caliber of retinal vein (ACvein) (B = −0.002, P = 0.045), whereas age, sex, BMI, AL, and IOP showed no significant impact on these metrics. Variations among graders significantly influenced most metrics; however, real-time MAP continued to predict retinal arteriolar caliber after adjusting for graders (B = −0.002, P = 0.03).

Conclusions

The mean arteriolar diameter measured using wide-field SSOCTA could serve as a highly sensitive indicator of systemic vascular changes.

Financial Disclosure(s)

Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

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宽视场扫描源OCT血管造影测量的平均动脉直径：一个高度敏感的平均动脉压指标

目的探讨基于宽视场扫描源OCT血管造影（SSOCTA）的浅视网膜表面图像的视网膜小动脉和小静脉指标，并评估其与正常样本中特定系统参数的关系。DesignCross-sectional研究。参与者：在西安交通大学第一附属医院门诊招募无高血压、糖尿病、重大眼疾病史的正常志愿者。符合条件的眼睛矫正视力为20/25或更好，眼压（IOP）不超过21 mmHg。方法对受试者双眼进行24 × 20 mm的SSOCTA扫描，同时测量眼轴长（AL）、IOP、实时平均动脉压（MAP）和体重指数（BMI）。手工分割视网膜小动脉和小静脉，并将其从盘缘到视网膜浅层的毛细血管连接处区分开来。使用ImageJ进行图像处理和计算。主要观察指标通过二值化血管图像计算动静脉平均直径、分形维数及动静脉比。使用广义线性混合模型来检验系统参数与这些指标之间的相关性。结果筛选后共纳入44例受试者的54只眼。单因素分析显示，MAP对视网膜动脉平均口径（B = - 0.003, P = 0.004）和视网膜静脉（ACvein）平均口径（B = - 0.002, P = 0.045）有显著的负面影响，而年龄、性别、BMI、AL和IOP对这些指标没有显著影响。评分者之间的差异显著影响了大多数指标；然而，调整分级后，实时MAP继续预测视网膜小动脉口径（B = - 0.002, P = 0.03）。结论大视场SSOCTA测量的动脉平均直径可作为全身性血管变化的敏感指标。财务披露专有或商业披露可在本文末尾的脚注和披露中找到。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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