On a nonautonomous nonlinear model for cell growth and division

Abstract

In this paper, we propose and analyze a nonautonomous, nonlinear size-structured population model that describes the growth and division of cells. By applying the monotone method based on a comparison principle, we establish the well-posedness of the model. We then investigate the long-term behavior of the solution using the upper–lower solution approach. Specifically, we derive conditions on the model parameters that determine the persistence or extinction of the cell population.