Role of RhoA-ROCK signaling inhibitor fasudil in Alzheimer disease

IF 2.6 3区心理学 Q2 BEHAVIORAL SCIENCES

Behavioural Brain Research Pub Date : 2025-03-03 DOI:10.1016/j.bbr.2025.115524

Hayder M. Al-kuraishy , Ghassan M. Sulaiman , Hamdoon A. Mohammed , Ali I. Al-Gareeb , Ali K. Albuhadily , Sohaib G. Mohammed

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引用次数: 0

Abstract

Alzheimer disease (AD) is the most common neurodegenerative brain disease linked with the development of dementia. AD neuropathology is characterized by the progressive accumulation of extracellular β-amyloid (Aβ) plaques and intracellular neurofibrillary tangles (NFTs). Different signaling pathways are involved in AD neuropathology through modulation of Aβ formation and tau protein hyperphosphorylation. One of these signaling is Rho-associated protein kinase (ROCK). RhoA-ROCK signaling boosts the production of Aβ through activation of β-secretase and augments the formation of NFTs. RhoA-ROCK signaling is also intricate in the development of oxidative stress and neuroinflammation. Consequently, targeting RhoA-ROCK signaling by specific inhibitors, such as fasudil, may decrease AD neuropathology. Therefore, this perspective aims to discuss the role of RhoA-ROCK signaling in the pathogenesis of AD and how fasudil could be effective in its treatment.

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来源期刊

Behavioural Brain Research 医学-行为科学

CiteScore

5.60

自引率

0.00%

发文量

383

审稿时长

61 days

期刊介绍： Behavioural Brain Research is an international, interdisciplinary journal dedicated to the publication of articles in the field of behavioural neuroscience, broadly defined. Contributions from the entire range of disciplines that comprise the neurosciences, behavioural sciences or cognitive sciences are appropriate, as long as the goal is to delineate the neural mechanisms underlying behaviour. Thus, studies may range from neurophysiological, neuroanatomical, neurochemical or neuropharmacological analysis of brain-behaviour relations, including the use of molecular genetic or behavioural genetic approaches, to studies that involve the use of brain imaging techniques, to neuroethological studies. Reports of original research, of major methodological advances, or of novel conceptual approaches are all encouraged. The journal will also consider critical reviews on selected topics.