Synthesis of spiroisoxazoline oxindoles by base-promoted annulation of oxime esters and isatins

IF 1.5 4区化学 Q3 CHEMISTRY, ORGANIC

Tetrahedron Letters Pub Date : 2025-03-06 DOI:10.1016/j.tetlet.2025.155506

Si-Wei Chen , Xu-Hua Hu , Ling Wu , Chun-Bao Miao , Xun-Xiang Guo

引用次数: 0

Abstract

A base-promoted annulation reaction of oxime esters and isatins has been developed for the facile and rapid synthesis of spiroisoxazoline oxindoles. This method demonstrates high efficiency, enabling the synthesis of a variety of spiroisoxazoline oxindoles with good to high yields under simple and mild conditions.

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碱促进肟酯和isatins环化法合成螺代异恶唑啉氧吲哚

为了方便、快速地合成螺异恶唑啉氧吲哚，建立了一种碱促进的肟酯和isatins环化反应。该方法效率高，可以在简单温和的条件下合成多种螺异恶唑啉氧吲哚，收率高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tetrahedron Letters 化学-有机化学

CiteScore

3.50

自引率

5.60%

发文量

521

审稿时长

28 days

期刊介绍： Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.