Role of cell-based therapies in digestive disorders: Obstacles and opportunities

IF 3.4 3区环境科学与生态学 Q3 CELL & TISSUE ENGINEERING

Regenerative Therapy Pub Date : 2025-03-04 DOI:10.1016/j.reth.2025.02.009

Guodong Liang , Yuehan Ma , Ping Deng , Shufeng Li , Chunyan He , Haihang He , Hairui Liu , Yunda Fan , Ze Li

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Abstract

Stem cell-based therapies have emerged as a promising frontier in the treatment of gastrointestinal disorders, offering potential solutions for challenges posed by conventional treatments. This review comprehensively examines recent advancements in cell-based therapeutic strategies, particularly focusing on stem cell applications, immunotherapy, and cellular therapies for digestive diseases. It highlights the successful differentiation of enteric neural progenitors from pluripotent stem cells and their application in animal models, such as Hirschsprung disease. Furthermore, the review evaluates clinical trials and experimental studies demonstrating the potential of stem cells in regenerating damaged tissues, modulating immune responses, and promoting healing in conditions like Crohn's disease and liver failure. By addressing challenges, such as scalability, immunogenicity, and ethical considerations, the review underscores the translational opportunities and obstacles in realizing the clinical potential of these therapies. Concluding with an emphasis on future directions, the study provides insights into optimizing therapeutic efficacy and fostering innovations in personalized medicine for digestive disorders.

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细胞疗法在消化系统疾病中的作用：障碍与机遇

基于干细胞的治疗已经成为治疗胃肠道疾病的一个有前途的前沿，为传统治疗带来的挑战提供了潜在的解决方案。本文综述了细胞治疗策略的最新进展，特别是干细胞应用、免疫治疗和消化系统疾病的细胞治疗。它强调了从多能干细胞成功分化肠神经祖细胞及其在动物模型中的应用，如巨结肠病。此外，该综述评估了证明干细胞在再生受损组织、调节免疫反应和促进克罗恩病和肝功能衰竭等疾病愈合方面具有潜力的临床试验和实验研究。通过解决诸如可扩展性、免疫原性和伦理考虑等挑战，该综述强调了实现这些疗法临床潜力的转化机会和障碍。最后强调了未来的发展方向，该研究为优化消化系统疾病的治疗效果和促进个性化医疗创新提供了见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Regenerative Therapy Engineering-Biomedical Engineering

CiteScore

6.00

自引率

2.30%

发文量

106

审稿时长

49 days

期刊介绍： Regenerative Therapy is the official peer-reviewed online journal of the Japanese Society for Regenerative Medicine. Regenerative Therapy is a multidisciplinary journal that publishes original articles and reviews of basic research, clinical translation, industrial development, and regulatory issues focusing on stem cell biology, tissue engineering, and regenerative medicine.