Exploring a conundrum: Evaluating the role of neoadjuvant chemotherapy preceding chemo-radiotherapy in locally advanced cervical cancer: A review article

IF 2 4区医学 Q2 OBSTETRICS & GYNECOLOGY

Taiwanese Journal of Obstetrics & Gynecology Pub Date : 2025-03-01 DOI:10.1016/j.tjog.2024.10.013

Sweta Soni , Deep Shankar Pruthi

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Abstract

In India, majority of women's with cervical cancer have locally advanced disease. The chemo-radiotherapy (CRT) followed by brachytherapy is the standard treatment for patients with locally advanced cervical cancer (LACC) disease for almost decades. But in developing countries like India with higher incidence and limited radiotherapy facilities, this may result in a delay in treatment initiation. These factors may further contribute to detrimental outcomes. Several researchers have tried to study role of neo-adjuvant chemotherapy (NACT) in LACC with the aim that neo-adjuvant chemotherapy may arrest the disease progression, prevent distant metastasis and therefore improve overall and disease-free survival. However, there is only limited literature so far, comparing NACT followed by CRT with the standard treatment arm alone. Therefore the review article aims to evaluate role of neo-adjuvant chemotherapy (NACT) followed by chemo-radiotherapy in LACC.

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探索一个难题：评估局部晚期宫颈癌化疗前新辅助化疗的作用：一篇综述文章

在印度，大多数患有宫颈癌的妇女都是局部晚期疾病。近几十年来，化疗放疗加近距离放疗是局部晚期宫颈癌（LACC）患者的标准治疗方法。但在印度等发病率较高且放射治疗设施有限的发展中国家，这可能导致治疗开始的延迟。这些因素可能进一步导致有害的结果。一些研究人员试图研究新辅助化疗（NACT）在LACC中的作用，目的是新辅助化疗可能会阻止疾病进展，防止远处转移，从而提高总生存率和无病生存率。然而，到目前为止，比较NACT后CRT与单独标准治疗组的文献有限。因此，本文旨在评价新辅助化疗（NACT）后放化疗在LACC中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Taiwanese Journal of Obstetrics & Gynecology OBSTETRICS & GYNECOLOGY-

CiteScore

3.60

自引率

23.80%

发文量

207

审稿时长

4-8 weeks

期刊介绍： Taiwanese Journal of Obstetrics and Gynecology is a peer-reviewed journal and open access publishing editorials, reviews, original articles, short communications, case reports, research letters, correspondence and letters to the editor in the field of obstetrics and gynecology. The aims of the journal are to: 1.Publish cutting-edge, innovative and topical research that addresses screening, diagnosis, management and care in women''s health 2.Deliver evidence-based information 3.Promote the sharing of clinical experience 4.Address women-related health promotion The journal provides comprehensive coverage of topics in obstetrics & gynecology and women''s health including maternal-fetal medicine, reproductive endocrinology/infertility, and gynecologic oncology. Taiwan Association of Obstetrics and Gynecology.