Piezoelectric catalyst BaTiO3 and K0.5Na0.5NbO3 induced cellular and antibacterial response in poly (vinylidene fluoride) for self-powered implants for orthopedic applications

IF 5.2 2区化学 Q1 CHEMISTRY, APPLIED

Catalysis Today Pub Date : 2025-02-28 DOI:10.1016/j.cattod.2025.115255

Kuntal Kumar Das , Urvashi Kesarwani , Ravi Prakash , Pralay Maiti , Om Shankar , Ashutosh Kumar Dubey

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引用次数: 0

Abstract

Despite of excellent biocompatibility of piezoelectric poly(vinylidene fluoride) (PVDF), lower resistance towards bacteria and piezoelectric coefficient restricts it’s widespread application as self-powered implant. Towards this end, this study investigates the effect of incorporation of piezo-catalysts BaTiO₃ (BT) and K_0.5Na_0.5NbO₃ (KNN) into PVDF on piezo-catalytic characteristics, cellular and antibacterial response. Thin films of PVDF and its composites were prepared using the solvent casting method and hot compression molding. The piezo-catalytic response is observed to be notably higher in the composites than that of pure PVDF. The measured values of voltage, and power for PVDF, PVDF-10 wt% BT (PVDF-10BT) and PVDF-10 wt% KNN (PVDF-10KNN) are (24 V, ∼4.4 µW/cm²), (92 V, ∼15.8 µW/cm²) and (103 V, ∼19.4 µW/cm²), respectively. The presence of piezo-catalyst BT and KNN significantly enhance the cell proliferation, osteogenic differentiation (ALP) of MG-63 osteoblast-like cells and hemocompatibility. Incorporation of piezo-catalysts is observed to improve significantly the antibacterial response against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) due to a higher production of reactive oxygen species. These results suggest that PVDF modified with BaTiO₃ and K_0.5Na_0.5NbO₃ piezo-catalysts are promising candidates as self-powered implants for orthopedic applications.

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来源期刊

Catalysis Today 化学-工程：化工

CiteScore

11.50

自引率

3.80%

发文量

573

审稿时长

2.9 months

期刊介绍： Catalysis Today focuses on the rapid publication of original invited papers devoted to currently important topics in catalysis and related subjects. The journal only publishes special issues (Proposing a Catalysis Today Special Issue), each of which is supervised by Guest Editors who recruit individual papers and oversee the peer review process. Catalysis Today offers researchers in the field of catalysis in-depth overviews of topical issues. Both fundamental and applied aspects of catalysis are covered. Subjects such as catalysis of immobilized organometallic and biocatalytic systems are welcome. Subjects related to catalysis such as experimental techniques, adsorption, process technology, synthesis, in situ characterization, computational, theoretical modeling, imaging and others are included if there is a clear relationship to catalysis.