Plasticity of the auditory cortex and brainstem in surgically induced unilaterally deaf adult humans with and without tinnitus

IF 3.7 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology Pub Date : 2025-02-27 DOI:10.1016/j.clinph.2025.02.259

MinChul Park , Greg A. O’Beirne , Philip A. Bird , Michael R.D. Maslin

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引用次数: 0

Abstract

Objective

Cortical auditory evoked potentials (CAEPs) and auditory brainstem responses (ABRs) were compared between surgically induced unilaterally deaf (UD) adult humans with tinnitus (UD+T), without tinnitus (UD-T), and with binaurally hearing controls (CO). We hypothesised increased CAEP amplitudes from UD+T individuals, and increased ABR amplitudes from all UD individuals.

Methods

Data were gathered from 34 individuals (8 UD-T, 13 UD+T, 13 CO) using a 64-channel BioSemi device. Stimuli were delivered monaurally at 60 dB nHL. Evoked potential amplitudes and scalp topographies were compared between groups.

Results

Only UD+T individuals showed higher N1 amplitude compared to the controls (1.48 versus 1.04 μV) over the ipsilateral hemisphere (relative to intact ear). Higher ABR wave III/V ratios were revealed in both UD groups (UD-T 0.426 and UD+T 0.317) compared with the CO group (0.213), regardless of channel.

Conclusions

Tinnitus is thought to be a perceptual correlate of deafferentation-induced activity increase within the central auditory system (CAS) and the present findings support this. However, increased CAEP amplitude was observed amongst UD+T individuals, while altered ABR amplitude was observed in all UD listeners, suggesting deafferentation alone is insufficient for tinnitus.

Significance

Deafferentation and associated increased brainstem activity may be necessary but insufficient for triggering tinnitus.

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来源期刊

Clinical Neurophysiology 医学-临床神经学

CiteScore

8.70

自引率

6.40%

发文量

932

审稿时长

59 days

期刊介绍： As of January 1999, The journal Electroencephalography and Clinical Neurophysiology, and its two sections Electromyography and Motor Control and Evoked Potentials have amalgamated to become this journal - Clinical Neurophysiology. Clinical Neurophysiology is the official journal of the International Federation of Clinical Neurophysiology, the Brazilian Society of Clinical Neurophysiology, the Czech Society of Clinical Neurophysiology, the Italian Clinical Neurophysiology Society and the International Society of Intraoperative Neurophysiology.The journal is dedicated to fostering research and disseminating information on all aspects of both normal and abnormal functioning of the nervous system. The key aim of the publication is to disseminate scholarly reports on the pathophysiology underlying diseases of the central and peripheral nervous system of human patients. Clinical trials that use neurophysiological measures to document change are encouraged, as are manuscripts reporting data on integrated neuroimaging of central nervous function including, but not limited to, functional MRI, MEG, EEG, PET and other neuroimaging modalities.