Dose-dependent inflammatory and neurotoxic effects of polypropylene microplastics in Nile tilapia evidenced by internal extractive electrospray ionization high-resolution mass spectrometry metabolomics
Xiaokang Wu, Susu Pan, Ming Li, Jiaxin Dong, Yining Wang, Chenni Huang, Tao Qiu, Yu Gu, Dapeng Liang
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引用次数: 0
Abstract
Polypropylene is widely used in textiles, injection molding, and film production, yet the metabolic toxicity of polypropylene microplastics is poorly known due to the limitations of analytical techniques. Here, we used internal extractive electrospray ionization coupled with high-resolution mass spectrometry and non-targeted metabolomics analysis to investigate the impact of polypropylene micro- and nanoplastics sizes and doses on metabolic dysregulation in Nile tilapia organs and tissues. Results show an upregulation of inflammatory mediators, including arachidonic acid and its derivatives, which affect critical metabolic pathways such as glycerophospholipid, arachidonic acid, and sphingolipid metabolisms. The inflammatory and neurotoxic effects exhibited a dose-dependent relationship.
期刊介绍：
Environmental Chemistry Letters explores the intersections of geology, chemistry, physics, and biology. Published articles are of paramount importance to the examination of both natural and engineered environments. The journal features original and review articles of exceptional significance, encompassing topics such as the characterization of natural and impacted environments, the behavior, prevention, treatment, and control of mineral, organic, and radioactive pollutants. It also delves into interfacial studies involving diverse media like soil, sediment, water, air, organisms, and food. Additionally, the journal covers green chemistry, environmentally friendly synthetic pathways, alternative fuels, ecotoxicology, risk assessment, environmental processes and modeling, environmental technologies, remediation and control, and environmental analytical chemistry using biomolecular tools and tracers.
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